Document Detail

Dietary lipids: an additional regulator of plasma levels of sex hormone binding globulin.
MedLine Citation:
PMID:  3558725     Owner:  NLM     Status:  MEDLINE    
The effect of dietary lipid consumption on plasma levels of sex-hormone binding globulin (SHBG), free testosterone and cholesterol was studied in 6 normal men. After consuming a diet with a high fat content (greater than 100 g fat/day) for two weeks, the mean plasma cholesterol level increased (p less than 0.02) while the mean SHBG level decreased (p less than 0.02). Changing the diet from one with a high fat to low fat content (less than 20 g fat/day) for a further two week period resulted in a significant reduction in mean plasma cholesterol level (p less than 0.001) while the mean SHBG level increased (p less than 0.01). The increase in plasma SHBG was associated with a significant decrease in the free testosterone fraction and free testosterone concentration. No significant changes were detected in plasma samples obtained from the same men during a control period. The results from this study demonstrate that dietary lipid intake is an additional factor involved in the regulation of plasma levels of SHBG.
M J Reed; R W Cheng; M Simmonds; W Richmond; V H James
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  64     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-05-20     Completed Date:  1987-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1083-5     Citation Subset:  AIM; IM    
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MeSH Terms
Cholesterol / blood
Dietary Fats / administration & dosage,  pharmacology*
Middle Aged
Sex Hormone-Binding Globulin / metabolism*
Testosterone / blood
Reg. No./Substance:
0/Dietary Fats; 0/Sex Hormone-Binding Globulin; 57-88-5/Cholesterol; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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