Document Detail

Dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey.
MedLine Citation:
PMID:  1595535     Owner:  NLM     Status:  MEDLINE    
Programmed electrical stimulation was used to examine the ability of long-term dietary lipid modulation to influence myocardial vulnerability to the induction of ventricular fibrillation in adult marmoset monkeys (Callithrix jacchus). Marmosets fed diets supplemented (to a total of 28.5% of the energy as fat) with polyunsaturated fatty acid (PUFA)-rich tuna fish oil or sunflower seed oil had significantly elevated mean ventricular fibrillation threshold compared with those fed a saturated animal fat supplemented diet or a reference diet not supplemented with fat (11.2% of the energy as fat). Fibrillation threshold was reduced during acute myocardial ischemia induced by coronary artery occlusion but still remained higher in the PUFA-fed animals than either the control or the ischemic threshold in reference or saturated fat supplemented animals. Dietary tuna fish oil was associated with a low incidence of sustained fibrillation episodes and no fatalities. These results indicate that myocardial substrate vulnerability to arrhythmic stimuli is increased during ischemia in a nonhuman primate model but dietary PUFA can reduce vulnerability under both normal and ischemic conditions. Reduced dietary fat intake alone was without effect.
P L McLennan; T M Bridle; M Y Abeywardena; J S Charnock
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  123     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-02     Completed Date:  1992-07-02     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1555-61     Citation Subset:  AIM; IM    
Cardiac Research Unit, C.S.I.R.O. Division of Human Nutrition, O'Halloran Hill, Australia.
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MeSH Terms
Cardiac Pacing, Artificial
Coronary Disease / physiopathology
Dietary Fats / pharmacology*
Differential Threshold
Isoproterenol / pharmacology
Ventricular Fibrillation / physiopathology*
Reg. No./Substance:
0/Dietary Fats; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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