| Dietary isothiocyanates, glutathione S-transferase M1 (GSTM1), and lung cancer risk in African Americans and Caucasians from Los Angeles County, California. | |
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MedLine Citation:
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PMID: 19838921 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Isothiocyanates, found in cruciferous vegetables, are anticarcinogenic. Racial differences in smoking do not fully account for the African-American excess lung cancer incidence. African Americans consume more cruciferous vegetables than U.S. Whites. Impact on lung cancer risk is unknown. The glutathione S transferase M1 (GSTM1) gene promotes urinary isothiocyanate excretion. We evaluated dietary isothiocyanates and lung cancer using a population-based case-control study of 933 African Americans and Caucasians (non-Hispanic U.S. White) from Los Angeles County, California (311 cases; 622 controls). Broccoli, cauliflower, greens, and cabbage food-frequency variables represented isothiocyanates. Isothiocyanates were protective for lung cancer risk. Adjusted odds ratio (OR) for the uppermost quartile > 80 micro mol isothiocyanates/wk, compared to lowest, was 0.65 [95% confidence interval (CI) = 0.41-1.00, trend P = 0.02]. Association was stronger among subjects with homozygous deletion of GSTM1 (OR = 0.52, 95% CI = 0.31-0.86) than subjects with at least one GSTM1 copy (OR = 0.77, 95% CI = 0.49-1.21). The difference was not statistically significant (P = 0.16). Despite African Americans consuming more cruciferous vegetables, the isothiocyanate association did not vary by race (P = 0.52). Reduced lung cancer risk with higher isothiocyanate intake may be slightly stronger among subjects with deletion of GSTM1. |
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Authors:
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Catherine L Carpenter; Mimi C Yu; Stephanie J London |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Nutrition and cancer Volume: 61 ISSN: 1532-7914 ISO Abbreviation: Nutr Cancer Publication Date: 2009 |
Date Detail:
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Created Date: 2009-10-19 Completed Date: 2009-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905040 Medline TA: Nutr Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 492-9 Citation Subset: IM |
Affiliation:
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David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1742, USA. ccarpenter@mednet.ucla.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Americans* / genetics Aged Aged, 80 and over Aging Analysis of Variance Brassicaceae / chemistry Case-Control Studies Confidence Intervals Diet* Diet Surveys European Continental Ancestry Group* / genetics Female Gene Deletion Genetic Predisposition to Disease Glutathione Transferase / deficiency, genetics* Health Status Disparities Humans Isothiocyanates / administration & dosage* Linear Models Los Angeles / epidemiology Lung Neoplasms / ethnology*, genetics, prevention & control Male Middle Aged Polymorphism, Genetic Probability Questionnaires Risk Factors Sex Characteristics Smoking |
| Grant Support | |
ID/Acronym/Agency:
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N01-PC-35136/PC/NCI NIH HHS; N01-PC-35139/PC/NCI NIH HHS; N02-PC-15105/PC/NCI NIH HHS; NCI P01-CA42710/CA/NCI NIH HHS; ZO1 ES49017/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Isothiocyanates; EC 2.5.1.18/Glutathione Transferase; EC 2.5.1.18/glutathione S-transferase M1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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