Document Detail

Dietary isoflavones during pregnancy and lactation provide cardioprotection to offspring rats in adulthood.
MedLine Citation:
PMID:  15778278     Owner:  NLM     Status:  MEDLINE    
In adult rats, elongation of cardiac myocytes (CMs) correlates with dilatation (and sometimes dysfunction) of cardiac ventricles. Although sex steroids may constitute one possible factor that affects the dimensions of CMs, studies on their effects in rodents is complicated by the fact that most commercial soy-based diets also contain abundant phytoestrogens. We report that feeding Wistar-Kyoto rat dams during gestation and lactation with a phytoestrogen-rich soy-based diet caused the CMs of their adult offspring to be shorter than in counterparts originating from mothers fed with a phytoestrogen-free casein-based diet. The soy-based diet had no such effects when given to rats after 6 wk of age, and its effects were replicated when supplementing the maternal casein-based diet with the isoflavones daidzein and genistein (the most abundant phytoestrogens in soy-based diets). In contrast to rats whose mothers had been fed with a soy-based diet, the hearts of adult rats raised with a casein-based diet only featured dilated eccentric hypertrophy and progressed toward congestive heart failure when further challenged. Thus the presence of isoflavones in the maternal diet provides cardioprotection to the hearts of their offspring during adulthood.
Emmanuelle Souzeau; Sonia Bélanger; Sylvie Picard; Christian F Deschepper
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2005-03-18
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  289     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-14     Completed Date:  2005-09-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H715-21     Citation Subset:  IM    
Experimental Cardiovascular Biology Research Unit, Institut de Recherches Cliniques de Montréal, 110 Pine Ave. W., Montréal, Quebec, Canada H2W 1R7.
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MeSH Terms
Cardiotonic Agents / administration & dosage*,  pharmacology
Caseins / administration & dosage,  pharmacology
Cell Size
Dietary Supplements
Genistein / administration & dosage,  pharmacology
Isoflavones / administration & dosage*,  pharmacology
Lactation / physiology*
Myocytes, Cardiac / cytology,  drug effects
Phytoestrogens / administration & dosage,  pharmacology
Pregnancy, Animal / physiology*
Prenatal Exposure Delayed Effects*
Rats, Inbred WKY
Soybeans / chemistry*
Grant Support
Reg. No./Substance:
0/Cardiotonic Agents; 0/Caseins; 0/Isoflavones; 0/Phytoestrogens; 446-72-0/Genistein; 486-66-8/daidzein

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