| Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse. | |
| | |
MedLine Citation:
|
PMID: 20354157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Iron overload can cause insulin deficiency, but in some cases this may be insufficient to result in diabetes. We hypothesized that the protective effects of decreased iron would be more significant with increased beta-cell demand and stress. Therefore, we treated the ob/ob mouse model of type 2 diabetes with an iron-restricted diet (35 mg/kg iron) or with an oral iron chelator. Control mice were fed normal chow containing 500 mg/kg iron. Neither treatment resulted in iron deficiency or anemia. The low-iron diet significantly ameliorated diabetes in the mice. The effect was long lasting and reversible. Ob/ob mice on the low-iron diet exhibited significant increases in insulin sensitivity and beta-cell function, consistent with the phenotype in mouse models of hereditary iron overload. The effects were not accounted for by changes in weight or feeding behavior. Treatment with iron chelation had a more dramatic effect, allowing the ob/ob mice to maintain normal glucose tolerance for at least 10.5 wk despite no effect on weight. Although dietary iron restriction preserved beta-cell function in ob/ob mice fed a high-fat diet, the effects on overall glucose levels were less apparent due to a loss of the beneficial effects of iron on insulin sensitivity. Beneficial effects of iron restriction were minimal in wild-type mice on normal chow but were apparent in mice on high-fat diets. We conclude that, even at "normal" levels, iron exerts detrimental effects on beta-cell function that are reversible with dietary restriction or pharmacotherapy. |
| | |
Authors:
|
Robert C Cooksey; Deborah Jones; Scott Gabrielsen; Jingyu Huang; Judith A Simcox; Bai Luo; Yudi Soesanto; Hugh Rienhoff; E Dale Abel; Donald A McClain |
Related Documents
:
|
9821337 - A field survey on the annoyance caused by sounds from large firearms and road traffic. 2673607 - Clinical pharmacokinetics of iron preparations. 8384957 - Electron paramagnetic resonance spectroscopy of stable free radicals in the liver compa... 1436777 - A guide to primary care of iron-deficiency anemia. 19762807 - Effect of the sampling device on fat and protein variation in cow milk samples obtained... 9405587 - Folate status response to controlled folate intake in pregnant women. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-03-30 |
Journal Detail:
|
Title: American journal of physiology. Endocrinology and metabolism Volume: 298 ISSN: 1522-1555 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-14 Completed Date: 2010-06-08 Revised Date: 2011-07-28 |
Medline Journal Info:
|
Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
|
Languages: eng Pagination: E1236-43 Citation Subset: IM |
Affiliation:
|
Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Calorimetry, Indirect Diabetes Mellitus, Type 2 / metabolism*, physiopathology, prevention & control Glucose / metabolism* Glucose Tolerance Test Insulin Resistance / physiology* Insulin-Secreting Cells / physiology* Iron Chelating Agents / pharmacology* Iron, Dietary / administration & dosage*, metabolism Mice Mice, Inbred C57BL Mice, Knockout Mice, Obese Mitochondria, Heart / metabolism Oxygen Consumption / physiology Regression Analysis |
| Grant Support | |
ID/Acronym/Agency:
|
DK-58512/DK/NIDDK NIH HHS; HL-73167/HL/NHLBI NIH HHS; R01 DK081842-03/DK/NIDDK NIH HHS; UL1-RR025764/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Iron Chelating Agents; 0/Iron, Dietary; 50-99-7/Glucose |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insu...
Next Document: Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by satura...