| Dietary interventions that lower lipoproteins containing apolipoprotein C-III are more effective in whites than in blacks: results of the OmniHeart trial. | |
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MedLine Citation:
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PMID: 20826623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Blacks have lower average triglyceride and LDL cholesterol concentrations than do whites but higher rates of coronary heart disease. Apolipoprotein (apo) C-III in VLDL and LDL stimulates atherogenic processes in vascular cells. In blacks, the concentration of lipoproteins with apo C-III is unknown, and the response to dietary strategies that lower triglyceride and apo C-III has not been investigated OBJECTIVE: We compared the concentration of and dietary effects on apo C-III-containing lipoproteins in blacks and whites. DESIGN: In a randomized, 3-period feeding study [OmniHeart (Optimal Macronutrient Intake Trial to Prevent Heart Disease)], we measured lipoprotein concentrations in 89 blacks and 73 whites who consumed self-selected diets (baseline) and after 3 healthful diets emphasizing carbohydrate, unsaturated fat, or protein. Participants had prehypertension or hypertension, and 79% were overweight or obese. RESULTS: While consuming self-selected diets, blacks had lower apo C-III in total plasma, VLDL, and LDL than did whites. Unsaturated fat and protein diets lowered plasma apo C-III (16% and 18%, respectively) and triglyceride (12% and 21%, respectively) in whites but not in blacks, reducing racial differences. Most important, blacks had a lower concentration of atherogenic LDL with apo C-III at baseline and after study diets (34-41% lower, P < 0.02). The molar ratio of apo E to apo B was higher in blacks than in whites in total plasma and LDL at baseline and after the study diets. CONCLUSIONS: Blacks have lower concentrations of atherogenic lipoproteins that contain apo C-III than do whites when consuming diverse diets and an attenuated dietary response of triglyceride and apo C-III. Dietary efforts to lower triglyceride and apo C-III may be more effective in whites than in blacks. The OmniHeart Trial was registered at www.clinicaltrials.gov as NCT00051350. |
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Authors:
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Jeremy D Furtado; Hannia Campos; Anne E Sumner; Lawrence J Appel; Vincent J Carey; Frank M Sacks |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-09-08 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 92 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-21 Completed Date: 2010-10-27 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 714-22 Citation Subset: AIM; IM |
Affiliation:
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Harvard School of Public Health, Boston, MA, USA. jfurtado@hsph.harvard.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00051350 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Continental Ancestry Group / statistics & numerical data* Aged Apolipoprotein C-III / blood* Apolipoproteins / blood Cholesterol, HDL / blood Coronary Disease / epidemiology, mortality Diet* European Continental Ancestry Group / statistics & numerical data* Female Heart Diseases / epidemiology Humans Hypertension / epidemiology Lipoproteins / metabolism* Lipoproteins, LDL / blood Lipoproteins, VLDL / blood Male Middle Aged Obesity / epidemiology Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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DK63214/DK/NIDDK NIH HHS; HL67098/HL/NHLBI NIH HHS; HL68712/HL/NHLBI NIH HHS; P30 DK040561-15/DK/NIDDK NIH HHS; RR02635/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein C-III; 0/Apolipoproteins; 0/Cholesterol, HDL; 0/Lipoproteins; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL; 0/Triglycerides |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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