| Dietary interventions for metabolic syndrome: role of modifying dietary fats. | |
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MedLine Citation:
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PMID: 19192424 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In humans, insulin sensitivity is relatively impaired by diets that are low in oleic acid (OA), a cis monounsaturated fatty acid (MUFA), or rich in trans MUFA or palmitic acid (PA), a saturated fatty acid (FA). Emerging evidence exists that PA, in contrast to OA, causes insulin resistance via stimulation of inflammatory signaling and production of cytosolic lipid compounds (diacylglycerol and ceramide), leading one to presume that dietary or pharmacologic maneuvers that facilitate transport of FA into the mitochondria would be beneficial. However, in some models, insulin resistance is caused by excessive FA transport into the mitochondria, coupled with deficient electron transport and possibly increased reactive oxygen species formation; PA may impair electron transport via effects on gene expression. A research challenge is to determine whether feeding humans diets with markedly different contents of PA and OA would alter insulin sensitivity and/or critical biochemical mechanisms impacting muscle insulin signaling. |
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Authors:
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Craig Lawrence Kien |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current diabetes reports Volume: 9 ISSN: 1539-0829 ISO Abbreviation: Curr. Diab. Rep. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-04 Completed Date: 2009-05-14 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101093791 Medline TA: Curr Diab Rep Country: United States |
Other Details:
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Languages: eng Pagination: 43-50 Citation Subset: IM |
Affiliation:
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University of Vermont College of Medicine, Department of Pediatrics, E203 Given Building, 89 Beaumont Avenue, Burlington, VT 05405-0068, USA. cl.kien@uvm.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Ceramides
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physiology Diet, Fat-Restricted* Dietary Fats* Fatty Acids / biosynthesis, metabolism Humans Insulin / physiology* Lipids / physiology Metabolic Syndrome X / diet therapy* Obesity / diet therapy* Oleic Acid / metabolism Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR 00034/RR/NCRR NIH HHS; M01 RR 00073/RR/NCRR NIH HHS; M01 RR00109/RR/NCRR NIH HHS; R01 073284//PHS HHS; R01 DK055384-05/DK/NIDDK NIH HHS; R01 DK073284-02/DK/NIDDK NIH HHS; R01 DK55384/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ceramides; 0/Dietary Fats; 0/Fatty Acids; 0/Lipids; 11061-68-0/Insulin; 112-80-1/Oleic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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