Document Detail

Dietary interventions in north Karelia, Finland and south Italy. Modification of thromboxane B2 formation in platelets of male subjects only.
MedLine Citation:
PMID:  3964338     Owner:  NLM     Status:  MEDLINE    
The effects of dietary interventions, based on changes of total fat, saturated fatty acids and cholesterol contents and of the polyunsaturated/saturated (P/S) fatty acid ratio of the diet, were studied in normal male and female subjects, living in North Karelia, Finland, and South Italy. In North Karelia the increase of P/S ratio (from 0.15 to 1.2) of the diet for a 6-week period resulted in reduced thromboxane B2 (TxB2) production by collagen-stimulated platelets only in male subjects, whereas plasma total, LDL and HDL cholesterol were reduced in both sexes. After a 6-week return to the original diet, plasma lipid levels were restored in all subjects. In the South Italy study, changes in platelet TxB2 production were observed only after return to the original diet in male subjects. Total and LDL cholesterol were significantly increased during the dietary intervention and returned toward baseline levels after switch back to the original diet. These data indicate that the increase of the P/S ratio in the diet reduces platelet TxB2 formation only in men.
E Tremoli; A Petroni; A Socini; P Maderna; S Colli; R Paoletti; C Galli; A Ferro-Luzzi; P Strazzullo; M Mancini
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Atherosclerosis     Volume:  59     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-05-15     Completed Date:  1986-05-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  101-11     Citation Subset:  IM    
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MeSH Terms
Blood Platelets / metabolism*
Cholesterol / blood
Collagen / pharmacology
Coronary Disease / prevention & control
Dietary Fats / administration & dosage,  pharmacology*
Fatty Acids / administration & dosage,  blood
Fatty Acids, Unsaturated / administration & dosage,  blood
Lipids / blood
Lipoproteins / blood
Middle Aged
Sex Factors
Thromboxane B2 / blood*
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Lipids; 0/Lipoproteins; 54397-85-2/Thromboxane B2; 57-88-5/Cholesterol; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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