| Dietary interventions affecting chylomicron and chylomicron remnant clearance. | |
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MedLine Citation:
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PMID: 9888649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interest in effects of diet on postprandial lipoproteins has increased in recent years as a result of accumulating evidence for adverse cardiovascular consequences of elevated concentrations of triglyceride rich lipoproteins. Particular attention has been given to ability of different fatty acids to modulate postprandial lipoprotein responses because of evidence for both harmful and protective cardiovascular properties of the saturated, monounsaturated and omega-6 and omega-3 polyunsaturated fatty acid (PUFA) classes. Evidence for direct atherogenic properties of chylomicron remnants has led to attempts to monitor effects of diet specifically on this lipoprotein class. Limitations in the methods employed to measure chylomicron remnants and the small number of human studies which have evaluated effects of meal, and background diet, fatty acid composition, makes it difficult to draw definitive conclusions at the present time. However consideration of data from both animal and human studies tends to support the conclusion that diets, and meals, rich in PUFA (particularly long chain omega-3 PUFA), result in attenuated postprandial responses of the intestinally-derived lipoproteins. Attenuated responses to high PUFA meals appear to be due to greater rates of clearance and greater activation of lipoprotein lipase (LPL). Attenuated responses to high PUFA background diets may be due to adaptive changes involving both accelerated rates of clearance in peripheral tissues and liver, as well as decreased output of the competitor for chylomicron clearance, very low density lipoprotein (VLDL). |
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Authors:
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C M Williams |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Atherosclerosis Volume: 141 Suppl 1 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-03-16 Completed Date: 1999-03-16 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: IRELAND |
Other Details:
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Languages: eng Pagination: S87-92 Citation Subset: IM |
Affiliation:
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Department of Food Science and Technology, University of Reading, UK. c.m.williams@reading.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chylomicrons / metabolism* Dietary Fats / administration & dosage*, metabolism* Humans Lipid Metabolism* Lipolysis |
| Chemical | |
Reg. No./Substance:
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0/Chylomicrons; 0/Dietary Fats |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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