| Dietary intervention with emphasis on folate intake reduces serum lipids but not plasma homocysteine levels in hyperlipidemic patients. | |
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MedLine Citation:
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PMID: 19083486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperlipidemia and hyperhomocysteinemia are regarded as major risk factors for cardiovascular disease. Medical nutrition therapy (MNT), which involves a combination of nutritional diagnosis, therapy, and counseling for at-risk patients, has been proposed as a protocol to control these risk factors. The purpose of this study was to investigate the effect of an intensive MNT, specifically tailored to Korean hyperlipidemic patients, on levels of serum lipids and plasma homocysteine. Forty hyperlipidemic patients with blood levels of total cholesterol > or = 200 mg/dL or triacylglycerol > or = 150 mg/dL were recruited from the Kyung Hee University Medical Center (Seoul, Korea). They were randomly divided into control (no treatment) or experimental (MNT treatment) groups. A registered dietitian performed MNT, emphasizing dietary folate intake based on the guidelines for Korean hyperlipidemic patients; this was performed 5 times during the 12 weeks of the experiment. After the MNT period, we observed that body mass index (P < .001) and fat percentage (P < .05) was significantly decreased in the experimental group but not in the control group. Daily energy consumption, as well as carbohydrate, fat, and cholesterol intakes, all decreased significantly (P < .05) in the MNT group, whereas folate intake increased (P < .05). Blood levels of triacylglycerol (-30.8%), total cholesterol (-20.9%), low-density lipoprotein cholesterol (-14.5%), and ratio of low-density lipoprotein/high-density lipoprotein (-17.1%) were significantly lower in the experimental group after MNT (P < .001) compared with the control group. Plasma homocysteine levels were unchanged (P = .98); however, the levels of folate (P < .01), vitamin B(6) (P < .01), and vitamin B(12) (P < .05) increased significantly in the experimental group. These results indicate that MNT, with an emphasis on folate intake, can be effective at reducing blood levels of lipids and improving the blood levels of folate, vitamin B(6), and vitamin B(12) in Korean hyperlipidemic patients. |
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Authors:
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Hyun-Jung Lim; Young-Min Choi; Ryowon Choue |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutrition research (New York, N.Y.) Volume: 28 ISSN: 1879-0739 ISO Abbreviation: Nutr Res Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-03-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8303331 Medline TA: Nutr Res Country: United States |
Other Details:
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Languages: eng Pagination: 767-74 Citation Subset: IM |
Affiliation:
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Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Seoul 130-701, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Body Mass Index Cardiovascular Diseases / prevention & control Chi-Square Distribution Diet Diet Records Female Folic Acid / administration & dosage* Homocysteine / blood* Humans Hyperhomocysteinemia / blood, complications, diet therapy* Hyperlipidemias / blood, complications, diet therapy* Korea Lipids / blood* Male Middle Aged Vitamins / analysis |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Vitamins; 454-28-4/Homocysteine; 59-30-3/Folic Acid |
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