Document Detail


Dietary intake of vitamin B-6, plasma pyridoxal 5'-phosphate, and homocysteine in Puerto Rican adults.
MedLine Citation:
PMID:  21034879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Vitamin B-6 is an important cofactor in many metabolic processes. However, vitamin B-6 intake and plasma status have not been well studied in the Puerto Rican population, a group with documented health disparities.
OBJECTIVE: To assess dietary intake of vitamin B-6, food sources, and plasma status of pyridoxal 5'-phosphate (PLP), and their associations with plasma homocysteine in 1,236 Puerto Rican adults, aged 45 to 75 years, living in the greater Boston area.
DESIGN: Baseline data were analyzed cross-sectionally.
METHOD: Questionnaire data were collected by home interview. Dietary intake was assessed with a semiquantitative food frequency questionnaire. Plasma PLP and homocysteine were assayed from blood samples collected in the home.
RESULTS: The mean daily intake of vitamin B-6 was 2.90 ± 1.28 mg for men and 2.61 ± 1.29 mg for women (P<0.001). Approximately 11% were deficient (PLP <4.94 ng/mL [PLP <20 nmol/L]) and another 17% insufficient (PLP ≥ 4.94 but <7.41 ng/mL [PLP ≥ 20 but <30 nmol/L]). Household income below the poverty threshold, physical inactivity, and current smoking were significantly associated with lower plasma PLP (P<0.05). Food groups contributing most to vitamin B-6 intake included ready-to-eat cereals, poultry, rice, potatoes, and dried beans. However, only intake of ready-to-eat cereals and use of supplements with vitamin B-6 were significantly associated with plasma PLP sufficiency (≥ 7.41 vs <7.41 ng/mL [PLP ≥ 30 vs <30 nmol/L], P<0.01). Both vitamin B-6 intake and PLP were significantly associated with plasma total homocysteine (P<0.001). The association between PLP and homocysteine remained statistically significant after further adjustment for plasma vitamin B-12 and folate (P=0.028).
CONCLUSIONS: Given the known importance of vitamin B-6 to health, the high prevalence of low vitamin B-6 status in this Puerto Rican population is of concern. Further work is needed to clarify the potential role that insufficient vitamin B-6 may have in relation to the observed health disparities in this population.
Authors:
Xingwang Ye; Janice E Maras; Peter J Bakun; Katherine L Tucker
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of the American Dietetic Association     Volume:  110     ISSN:  1878-3570     ISO Abbreviation:  J Am Diet Assoc     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-11-30     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  7503061     Medline TA:  J Am Diet Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1660-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 American Dietetic Association. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Boston / epidemiology
Cross-Sectional Studies
Diet / ethnology
Female
Health Status Disparities*
Hispanic Americans
Homocysteine / blood*
Humans
Male
Middle Aged
Puerto Rico / ethnology
Pyridoxal Phosphate / blood*
Questionnaires
Vitamin B 6 / administration & dosage*,  metabolism
Vitamin B 6 Deficiency / epidemiology*
Grant Support
ID/Acronym/Agency:
P01 AG023394/AG/NIA NIH HHS; P01 AG023394-05/AG/NIA NIH HHS; P01AG023394/AG/NIA NIH HHS; R01 AG027087/AG/NIA NIH HHS; R01 AG027087-03/AG/NIA NIH HHS; R01AG02708/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0LVT1QZ0BA/Homocysteine; 5V5IOJ8338/Pyridoxal Phosphate; 8059-24-3/Vitamin B 6
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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