Document Detail

Dietary intake and plasma lipid levels: lessons from a study of the diet of health conscious groups.
MedLine Citation:
PMID:  2369659     Owner:  NLM     Status:  MEDLINE    
AIM: To re-examine the contentious relation between diet and plasma lipids within a population. DESIGN: Cross sectional sample from a large prospective cohort study of people eating different diets in Britain. Blood samples and diet records collected from subjects. SUBJECTS: Volunteers eating one of four distinct diets--namely, vegans, vegetarians, fish eaters who do not eat meat, and meat eaters. 52 Subjects selected from each group. METHODS: Examination of the relation between nutritional intake recorded in a four day dietary record and plasma lipid concentrations of subjects measured in blood samples collected previously. RESULTS: After controlling for age, sex, and body mass index, the correlation between plasma total cholesterol and the Keys score (which includes dietary cholesterol and saturated and polyunsaturated fat) was 0.37 (p less than 0.001). The mean saturated fat intake in all groups was low (6-14% of energy), but polyunsaturated fat intake was high, so mean total fat intake was generally above that recommended. A high dietary fibre intake was not associated with high carbohydrate intake. Plasma high density lipoprotein values were not associated with any measure of fat intake, but there was a significant correlation of 0.24 between high density lipoprotein values and alcohol intake. CONCLUSIONS: The nature rather than quantity of dietary fat is an important determinant of cholesterol concentrations. Health conscious individuals select a fat modified, rather than a low fat--high carbohydrate diet. National cholesterol lowering dietary advice should be reconsidered.
M Thorogood; L Roe; K McPherson; J Mann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  300     ISSN:  0959-8138     ISO Abbreviation:  BMJ     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-23     Completed Date:  1990-08-23     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1297-301     Citation Subset:  AIM; IM    
Department of Public Health and Primary Care, Radcliffe Infirmary, Oxford.
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MeSH Terms
Body Constitution
Cholesterol, HDL / blood*
Cholesterol, LDL / blood*
Cross-Sectional Studies
Diet Fads
Diet, Vegetarian
Dietary Fats / administration & dosage
Dietary Fats, Unsaturated / administration & dosage
Energy Intake
Fish Products
Health Behavior*
Meat Products
Middle Aged
Prospective Studies
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Dietary Fats; 0/Dietary Fats, Unsaturated
Comment In:
BMJ. 1990 Jul 7;301(6742):43-4   [PMID:  2383713 ]

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