Document Detail


Dietary intake of n-3 polyunsaturated fatty acids is inversely associated with CRP levels, especially among male smokers.
MedLine Citation:
PMID:  18343384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine whether dietary intake of n-3 polyunsaturated fatty acid (n-3PUFA) is associated with serum C-reactive protein (CRP) levels with regard to smoking status in the Japanese general population in a cross-sectional study. METHODS AND RESULTS: A total of 14,191 participants aged 40-69 years were enrolled and divided into quartile groups according to their intake of n-3PUFA. Multivariate-adjusted logarithm-transformed CRP levels were compared between the quartile groups with regard to smoking status after adjusting for traditional risk factors and intake of saturated fatty acids. Adjusted CRP levels were inversely associated with dietary intake of n-3PUFA for both the male subjects and female subjects (p<0.05 for trend). A linear trend was not seen between intake of n-3PUFA and adjusted CRP levels in male nonsmokers. Adjusted CRP level in the lowest quartile group of n-3PUFA was significantly higher than the levels in other groups in male smokers. CONCLUSION: Sufficient dietary intake of n-3PUFA may attenuate inflammatory reaction and this effect is more evident among high-risk populations such as male smokers although the small numbers of female ex-smokers and nonsmokers limited statistical power to draw strong conclusions about these groups.
Authors:
Masaki Ohsawa; Kazuyoshi Itai; Toshiyuki Onoda; Kozo Tanno; Satoshi Sasaki; Motoyuki Nakamura; Akira Ogawa; Kiyomi Sakata; Kazuko Kawamura; Toru Kuribayashi; Yuki Yoshida; Akira Okayama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-17
Journal Detail:
Title:  Atherosclerosis     Volume:  201     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2009-10-30     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  184-91     Citation Subset:  IM    
Affiliation:
Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University, Japan. masakio@iwate-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
C-Reactive Protein / metabolism*
Cohort Studies
Cross-Sectional Studies
Diet*
Fatty Acids, Omega-3 / administration & dosage*
Female
Health Status
Health Surveys
Humans
Japan
Life Style
Male
Middle Aged
Risk Factors
Sex Factors
Smoking / blood*
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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