Document Detail


Dietary intake of n-3 fatty acids and colorectal cancer risk: a meta-analysis of data from 489 000 individuals.
MedLine Citation:
PMID:  22906228     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Preclinical studies have suggested an anti-colorectal cancer effect of n-3 fatty acids, yet epidemiological studies have reported mixed results. The goal of the present meta-analysis was to examine the association between the dietary intake of n-3 fatty acids and colorectal cancer risk by conducting a meta-analysis of prospective cohort studies. We searched the PubMed database up to February 2012 to identify eligible studies. Either a fixed- or random-effects model was used to obtain a pooled relative risk (RR) comparing the highest intake of n-3 fatty acids with the lowest. We conducted subgroup analyses according to sex, geographic region, length of follow-up, cancer site and type of n-3 fatty acids. We included seven prospective studies in the meta-analysis, comprising 489 465 participants and 4656 incident cases. The pooled RR of colorectal cancer in relation to n-3 fatty acids was 0·98 (95 % CI 0·88, 1·09). The results from subgroup analysis indicated a significant reduced risk of colorectal cancer in relation to n-3 fatty acids among men (RR 0·87, 95 % CI 0·75, 1·00; n 4). No significant association was observed in other subgroups. There was no evidence of publication bias as suggested by Begg's test (P = 0·76) and Egger's test (P = 0·66). The present meta-analysis showed insufficient evidence of a protective effect of n-3 fatty acids on colorectal cancer risk. However, a reduced risk observed in men warrants further investigation.
Authors:
Xiao-Jian Shen; Jun-Dong Zhou; Jia-Yi Dong; Wei-Qun Ding; Jin-Chang Wu
Related Documents :
18186338 - Investigations of the diurnal cycle and mixing state of oxalic acid in individual parti...
19748938 - Experimental design and process analysis for acidic leaching of metal-rich glass wastes.
18367828 - Inhibition of iron-catalyzed oxidations by attainable uric acid and ascorbic acid level...
1630718 - Treatment of iron-deficiency anemia complicated by scurvy and folic acid deficiency.
9350308 - A new mutation in the human lipoprotein lipase gene causing familial hyperchylomicronae...
24799958 - Quantum entanglement in photoactive prebiotic systems.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-20
Journal Detail:
Title:  The British journal of nutrition     Volume:  -     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-7     Citation Subset:  -    
Affiliation:
Department of Radiotherapy, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Six regulatory elements lying in the promoter region imply the functional diversity of chloroplast G...
Next Document:  Temporary Peritoneal Dialysis in Newborns and Children: A Single-Center Experience over Five Years.