| Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a case-control study in Japan. | |
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MedLine Citation:
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PMID: 20338075 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson's disease (PD) through neurotoxic effects; thus, increasing intake of B vitamins involved in the regulation of homocysteine metabolism might decrease the risk of PD through decreasing plasma homocysteine. However, epidemiological evidence for the association of dietary B vitamins with PD is sparse, particularly in non-Western populations. We conducted a hospital-based case-control study in Japan to examine associations between dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and the risk of PD. Patients with PD diagnosed using the UK PD Society Brain Bank criteria (n 249) and controls without neurodegenerative diseases (n 368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semi-quantitative, comprehensive diet history questionnaire. After adjustment for potential dietary and non-dietary confounding factors, intake of folate, vitamin B12 and riboflavin was not associated with the risk of PD (P for trend = 0.87, 0.70 and 0.11, respectively). However, low intake of vitamin B6 was associated with an increased risk of PD, independent of potential dietary and non-dietary confounders. Multivariate OR (95 % CI) for PD in the first, second, third and fourth quartiles of vitamin B6 were 1 (reference), 0.56 (0.33, 0.94), 0.69 (0.38, 1.25) and 0.48 (0.23, 0.99), respectively (P for trend = 0.10). In conclusion, in the present case-control study in Japan, low intake of vitamin B6, but not of folate, vitamin B12 or riboflavin, was independently associated with an increased risk of PD. |
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Authors:
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Kentaro Murakami; Yoshihiro Miyake; Satoshi Sasaki; Keiko Tanaka; Wakaba Fukushima; Chikako Kiyohara; Yoshio Tsuboi; Tatsuo Yamada; Tomoko Oeda; Takami Miki; Nobutoshi Kawamura; Nobutaka Sakae; Hidenao Fukuyama; Yoshio Hirota; Masaki Nagai; |
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Publication Detail:
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Type: Journal Article Date: 2010-03-26 |
Journal Detail:
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Title: The British journal of nutrition Volume: 104 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-25 Completed Date: 2010-09-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 757-64 Citation Subset: IM |
Affiliation:
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Department of Social and Preventive Epidemiology, School of Public Health, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan. kenmrkm@m.u-tokyo.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Case-Control Studies Diet* Diet Surveys Female Folic Acid / administration & dosage* Humans Japan Male Middle Aged Odds Ratio Parkinson Disease / etiology* Questionnaires Riboflavin / administration & dosage* Risk Factors Vitamin B 12 / administration & dosage* Vitamin B 6 / administration & dosage* Vitamin B Complex / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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12001-76-2/Vitamin B Complex; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12; 8059-24-3/Vitamin B 6; 83-88-5/Riboflavin |
| Investigator | |
Investigator/Affiliation:
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Yasuhiko Baba / ; Tomonori Kobayashi / ; Hideyuki Sawada / ; Eiji Mizuta / ; Nagako Murase / ; Tsuyoshi Tsutada / ; Hiroyuki Shimada / ; Jun-ichi Kira / ; Tameko Kihira / ; Tomoyoshi Kondo / ; Hidekazu Tomimoto / ; Takayuki Taniwaki / ; Hiroshi Sugiyama / ; Sonoyo Yoshida / ; Harutoshi Fujimura / ; Tomoko Saito / ; Kyoko Saida / ; Junko Fujitake / ; Naoki Fujii / ; Masatoshi Naito / ; Jun Arimizu / ; Takashi Nakagawa / ; Hirofumi Harada / ; Takayuki Sueta / ; Toshihiro Kikuta / ; George Umemoto / ; Eiichi Uchio / ; Hironori Migita / ; Kenichi Kazuki / ; Yoichi Ito / ; Hiroyoshi Iwaki / ; Kunihiko Siraki / ; Shinsuke Ataka / ; Hideo Yamane / ; Rie Tochino / ; Teruichi Harada / ; Yasushi Iwashita / ; Motoyuki Shimizu / ; Kenji Seki / ; Keiji Ando / |
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