Document Detail


Dietary intake estimate for perfluorooctanesulphonic acid (PFOS) and other perfluorocompounds (PFCs) in UK retail foods following determination using standard addition LC-MS/MS.
MedLine Citation:
PMID:  20198525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The analysis of 252 food samples (UK-produced and imported) purchased from a variety of retail outlets in the UK was undertaken for the presence of perfluorooctanesulphonic acid (PFOS), perfluorooctanoic acid (PFOA) and nine other perfluorocompounds (PFCs). A limit of quantification (LOQ) of 1 microg/kg was achieved for all target analytes, in all samples. Standard addition was used for quantification of PFC levels. All 11 of the targeted PFCs were detected in 75 individual food items. In 70% of the samples, including all meat other than offal, none of the analytes were present above the LOD. The highest levels found were 59 microg/kg perfluorooctanesulphonic acid (PFOS) and 63 microg/kg total PFCs (SigmaPFCs) in an eel sample, and 40 microg/kg PFOS (62 microg/kg SigmaPFCs) in a whitebait sample. The highest level in an offal sample was 10 microg/kg, in a wild roe deer liver. There were six samples with SigmaPFCs >15 microg/kg (fish, shellfish, crustaceans), a further seven samples with SigmaPFCs ranging 11-15 microg/kg (including a liver), nine with SigmaPFCs ranging 6-10 microg/kg (fish and livers), 31 with SigmaPFCs in the range 2-5 microg/kg (including kidneys, popcorn and processed peas) and a further 22 with SigmaPFCs close to the LOD of 1 microg/kg (including eggs and potatoes). These concentrations indicate that UK consumers are being exposed to a low level of PFC contamination from food. The estimated upper bound dietary intake of 10 ng/kg bodyweight (bw)/day of PFOS for average adult consumers is well below the 0.15 microg (150 ng)/kg bw tolerable daily intake (TDI) set by the European Food Safety Authority. The lower bound adult dietary intake estimate of 1 ng/kg bw/day is similar to estimates undertaken and reported in countries such as Canada, Germany and Spain.
Authors:
D B Clarke; V A Bailey; A Routledge; A S Lloyd; S Hird; D N Mortimer; M Gem
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment     Volume:  27     ISSN:  1944-0057     ISO Abbreviation:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-17     Completed Date:  2010-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485040     Medline TA:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Country:  England    
Other Details:
Languages:  eng     Pagination:  530-45     Citation Subset:  IM    
Affiliation:
Department for Environment, Food and Rural Affairs, Food and Environment Research Agency, York YO411LZ, UK. don.clarke@fera.gsi.gov.uk
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Alkanesulfonic Acids / administration & dosage,  analysis*,  toxicity
Animals
Child
Child, Preschool
Chromatography, High Pressure Liquid / methods*
Diet*
Fishes
Fluorocarbons / administration & dosage,  analysis*,  toxicity
Food Contamination / analysis*
Great Britain
Humans
Infant
Infant, Newborn
Kidney / chemistry
Liver / chemistry
Maximum Allowable Concentration
Meat / analysis
Seafood / analysis
Shellfish / analysis
Tandem Mass Spectrometry / methods*
Chemical
Reg. No./Substance:
0/Alkanesulfonic Acids; 0/Fluorocarbons; 1763-23-1/perfluorooctane sulfonic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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