Document Detail

Dietary intake associated with serum versus urinary carboxymethyl-lysine, a major advanced glycation end product, in adults: the Energetics Study.
MedLine Citation:
PMID:  21792213     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/OBJECTIVES: Advanced glycation end products (AGEs) are implicated in the pathogenesis of atherosclerosis, diabetes and kidney disease. The objective was to describe dietary intake, the dominant source of exposure to AGEs, with carboxymethyl-lysine (CML), a major AGE, in serum and urine, respectively.
SUBJECTS/METHODS: Serum and urinary CML were measured in 261 adults, aged 21-69 years, and compared with diet as assessed by six separate 24-h dietary recalls.
RESULTS: Median (25th, 75th percentile) serum and urinary CML concentrations were 686 (598, 803) μg/l and 1023 (812, 1238) μg/gm creatinine. There was no correlation between serum and urinary CML (r=-0.02, P=0.78). Serum CML was positively correlated with intake of soy, fruit juice, cold breakfast cereal, non-fat milk, whole grains, fruit, non-starchy vegetables and legumes, and negatively correlated with intake of red meat. Intake of fast food was not significantly correlated with serum CML. Urinary CML was positively correlated with intake of starchy vegetables, whole grains, sweets, nuts/seeds and chicken, and negatively correlated with intake of fast foods. Intake of AGE-rich foods such as fried chicken, French fries, bacon/sausage and crispy snacks were not significantly correlated with serum or urinary CML, except for a significant negative correlation between fried chicken and serum CML.
CONCLUSIONS: These findings suggest that the high consumption of foods considered high in CML is not a major determinant of either serum or urinary CML. Further work is needed to understand the relationship of AGEs in blood and urine with the metabolism of dietary AGEs.
R D Semba; A Ang; S Talegawkar; C Crasto; M Dalal; P Jardack; M G Traber; L Ferrucci; L Arab
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2011-07-27
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  66     ISSN:  1476-5640     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-04     Completed Date:  2012-05-22     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  3-9     Citation Subset:  IM    
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
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MeSH Terms
Atherosclerosis / etiology
Diabetes Mellitus / etiology
Glycosylation End Products, Advanced / blood,  metabolism*,  urine
Kidney Diseases / etiology
Lysine / analogs & derivatives*,  blood,  metabolism,  urine
Middle Aged
Young Adult
Grant Support
R01 AG027012/AG/NIA NIH HHS; R01 AG027012/AG/NIA NIH HHS; R01 AG029148/AG/NIA NIH HHS; R01 AG029148/AG/NIA NIH HHS; R01 CA105048/CA/NCI NIH HHS; R01 CA105048/CA/NCI NIH HHS; R01 HL094507/HL/NHLBI NIH HHS; R01 HL094507/HL/NHLBI NIH HHS; R37 AG019905/AG/NIA NIH HHS; R37 AG019905/AG/NIA NIH HHS
Reg. No./Substance:
0/Glycosylation End Products, Advanced; 56-87-1/Lysine; 5746-04-3/N(6)-carboxymethyllysine

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