Document Detail

Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study.
MedLine Citation:
PMID:  12076219     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Oxidative processes have been suggested as elements in the development of Alzheimer disease (AD), but whether dietary intake of vitamin E and other antioxidant nutrients prevents its development is unknown.
OBJECTIVE: To examine whether intake of antioxidant nutrients, vitamin E, vitamin C, and beta carotene is associated with incident AD.
DESIGN, SETTING, AND PARTICIPANTS: Prospective study, conducted from 1993 to 2000, of individuals selected in a stratified random sample of community-dwelling residents. The 815 residents 65 years and older were free of AD at baseline and were followed up for a mean of 3.9 years. They completed food frequency questionnaires an average of 1.7 years after baseline.
MAIN OUTCOME MEASURE: Incident AD diagnosed in clinical evaluations with standardized criteria.
RESULTS: Increasing vitamin E intake from foods was associated with decreased risk of developing AD after adjustment for age, education, sex, race, APOE epsilon 4, and length of follow-up. Relative risks (95% confidence intervals [CIs]) from lowest to highest quintiles of intake were 1.00, 0.71 (0.24-2.07), 0.62 (0.26-1.45), 0.71 (0.27-1.88), and 0.30 (0.10-0.92) (P for trend =.05). The protective association of vitamin E was observed only among persons who were APOE epsilon 4 negative. Adjustment for other dietary factors reduced the protective association. After adjustment for baseline memory score, the risk was 0.36 (95% CI, 0.11-1.17). Intake of vitamin C, beta carotene, and vitamin E from supplements was not significantly associated with risk of AD.
CONCLUSION: This study suggests that vitamin E from food, but not other antioxidants, may be associated with a reduced risk of AD. Unexpectedly, this association was observed only among individuals without the APOE epsilon 4 allele.
Martha Clare Morris; Denis A Evans; Julia L Bienias; Christine C Tangney; David A Bennett; Neelum Aggarwal; Robert S Wilson; Paul A Scherr
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  JAMA     Volume:  287     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-21     Completed Date:  2002-07-02     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3230-7     Citation Subset:  AIM; IM    
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MeSH Terms
African Continental Ancestry Group / genetics
Alzheimer Disease / epidemiology*,  etiology,  genetics
Antioxidants / metabolism*,  pharmacology
Apolipoprotein E4
Apolipoproteins E / genetics
Ascorbic Acid / metabolism,  pharmacology
Cluster Analysis
Dietary Supplements
European Continental Ancestry Group / genetics
Models, Statistical
Nutrition Assessment
Oxidative Stress
Prospective Studies
Vitamin E / metabolism,  pharmacology
beta Carotene / metabolism,  pharmacology
Grant Support
Reg. No./Substance:
0/Antioxidants; 0/Apolipoprotein E4; 0/Apolipoproteins E; 01YAE03M7J/beta Carotene; 1406-18-4/Vitamin E; PQ6CK8PD0R/Ascorbic Acid
Comment In:
JAMA. 2002 Nov 13;288(18):2265; author reply 2265-6   [PMID:  12425702 ]
JAMA. 2002 Jun 26;287(24):3261-3   [PMID:  12076225 ]

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