| Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. | |
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MedLine Citation:
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PMID: 12076219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Oxidative processes have been suggested as elements in the development of Alzheimer disease (AD), but whether dietary intake of vitamin E and other antioxidant nutrients prevents its development is unknown. OBJECTIVE: To examine whether intake of antioxidant nutrients, vitamin E, vitamin C, and beta carotene is associated with incident AD. DESIGN, SETTING, AND PARTICIPANTS: Prospective study, conducted from 1993 to 2000, of individuals selected in a stratified random sample of community-dwelling residents. The 815 residents 65 years and older were free of AD at baseline and were followed up for a mean of 3.9 years. They completed food frequency questionnaires an average of 1.7 years after baseline. MAIN OUTCOME MEASURE: Incident AD diagnosed in clinical evaluations with standardized criteria. RESULTS: Increasing vitamin E intake from foods was associated with decreased risk of developing AD after adjustment for age, education, sex, race, APOE epsilon 4, and length of follow-up. Relative risks (95% confidence intervals [CIs]) from lowest to highest quintiles of intake were 1.00, 0.71 (0.24-2.07), 0.62 (0.26-1.45), 0.71 (0.27-1.88), and 0.30 (0.10-0.92) (P for trend =.05). The protective association of vitamin E was observed only among persons who were APOE epsilon 4 negative. Adjustment for other dietary factors reduced the protective association. After adjustment for baseline memory score, the risk was 0.36 (95% CI, 0.11-1.17). Intake of vitamin C, beta carotene, and vitamin E from supplements was not significantly associated with risk of AD. CONCLUSION: This study suggests that vitamin E from food, but not other antioxidants, may be associated with a reduced risk of AD. Unexpectedly, this association was observed only among individuals without the APOE epsilon 4 allele. |
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Authors:
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Martha Clare Morris; Denis A Evans; Julia L Bienias; Christine C Tangney; David A Bennett; Neelum Aggarwal; Robert S Wilson; Paul A Scherr |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: JAMA : the journal of the American Medical Association Volume: 287 ISSN: 0098-7484 ISO Abbreviation: JAMA Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-21 Completed Date: 2002-07-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7501160 Medline TA: JAMA Country: United States |
Other Details:
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Languages: eng Pagination: 3230-7 Citation Subset: AIM; IM |
Affiliation:
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Rush Institute for Healthy Aging, Rush-Presbyterian-St Luke's Medical Center, 1645 W Jackson, Suite 675, Chicago, IL 60612, USA. mmorris@rush.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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African Continental Ancestry Group
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genetics Aged Alzheimer Disease / epidemiology*, etiology, genetics Antioxidants / metabolism*, pharmacology Apolipoprotein E4 Apolipoproteins E / genetics Ascorbic Acid / metabolism, pharmacology Cluster Analysis Dietary Supplements European Continental Ancestry Group / genetics Female Humans Male Models, Statistical Nutrition Assessment Oxidative Stress Prospective Studies Risk Vitamin E / metabolism, pharmacology beta Carotene / metabolism, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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AG11101/AG/NIA NIH HHS; AG13170/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Apolipoprotein E4; 0/Apolipoproteins E; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 7235-40-7/beta Carotene |
| Comments/Corrections | |
Comment In:
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JAMA. 2002 Nov 13;288(18):2265; author reply 2265-6
[PMID:
12425702
]
JAMA. 2002 Jun 26;287(24):3261-3 [PMID: 12076225 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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