| Dietary insulin load, dietary insulin index, and colorectal cancer. | |
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MedLine Citation:
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PMID: 20924099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Circulating insulin levels have been positively associated with risk of colorectal cancer; however, it remains unclear whether a diet inducing an elevated insulin response influences colorectal cancer risk. On the basis of a novel insulin index for individual foods, we estimated insulin demand for overall diets and assessed its association with colorectal cancer in the Nurses' Health Study and Health Professionals Follow-up Study. METHODS: We followed 86,740 women and 46,146 men who were free of cancer and diabetes at baseline and identified a total of 2,481 colorectal cancer cases during up to 26 years of follow-up. Dietary insulin load was calculated as a function of food insulin index and the energy content of individual foods was reported on food frequency questionnaires. Average dietary insulin index was calculated by dividing the dietary insulin load by the total energy intake. RESULTS: Dietary insulin load and dietary insulin index were not associated with risk of colorectal cancer. Comparing the highest with the lowest quintiles, the pooled multivariate relative risks of colorectal cancer were 0.91 (95% CI = 0.79-1.05) for dietary insulin load and 0.93 (95% CI = 0.81-1.08) for dietary insulin index. Body mass index and physical activity did not modify the association of dietary insulin load or index with colorectal cancer. CONCLUSION: A diet high in foods that increase postprandial insulin levels did not increase the risk of colorectal cancer in this large prospective study. IMPACT: This study is the first to investigate insulin index and load in relation to colorectal cancer. |
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Authors:
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Ying Bao; Katharina Nimptsch; Jeffrey A Meyerhardt; Andrew T Chan; Kimmie Ng; Dominique S Michaud; Jennie C Brand-Miller; Walter C Willett; Edward Giovannucci; Charles S Fuchs |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-05 |
Journal Detail:
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Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: 19 ISSN: 1538-7755 ISO Abbreviation: Cancer Epidemiol. Biomarkers Prev. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-15 Completed Date: 2011-04-06 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: United States |
Other Details:
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Languages: eng Pagination: 3020-6 Citation Subset: IM |
Copyright Information:
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©2010 AACR. |
Affiliation:
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Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. ying.bao@channing.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Colorectal Neoplasms / metabolism* Diet* Dietary Carbohydrates Female Food Habits Humans Insulin / metabolism* Male Middle Aged Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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P01 CA055075-190002/CA/NCI NIH HHS; P01 CA087969-117546/CA/NCI NIH HHS; P01 CA087969-12/CA/NCI NIH HHS; P01 CA55075/CA/NCI NIH HHS; P01 CA87969/CA/NCI NIH HHS; P50 CA127003/CA/NCI NIH HHS; P50 CA127003-05/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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