Document Detail

Dietary influences on the antiparkinsonian response to levodopa.
MedLine Citation:
PMID:  3632369     Owner:  NLM     Status:  MEDLINE    
The ability of dietary factors to modify the response to levodopa was evaluated in six patients with idiopathic Parkinson's disease who manifested fluctuations in motor performance. The single oral administration of a high-protein formula substantially elevated plasma large neutral amino acid levels, and prematurely terminated the antiparkinsonian response to levodopa/carbidopa. In contrast, during oral or intravenous administration of levodopa, the ingestion of diets meeting the recommended daily allowance (RDA) for protein had no significant effect on plasma levodopa or large neutral amino acid levels or variance, nor on parkinsonian scores or variance. The results suggest that while protein intake in excess of the RDA can diminish the antiparkinsonian response to orally administered levodopa/carbidopa in patients with advanced disease, diets adhering to RDA protein guidelines have no clinically appreciable effect.
J L Juncos; G Fabbrini; M M Mouradian; C Serrati; T N Chase
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  44     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-10-22     Completed Date:  1987-10-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1003-5     Citation Subset:  AIM; IM    
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MeSH Terms
Amino Acids / blood*
Carbidopa / therapeutic use
Dietary Proteins / pharmacology*
Levodopa / blood,  therapeutic use*
Middle Aged
Parkinson Disease / blood,  drug therapy*
Reg. No./Substance:
0/Amino Acids; 0/Dietary Proteins; 0/Levodopa; 38821-49-7/Carbidopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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