Document Detail


Dietary-induced pre-translational control of rat fatty acid synthase.
MedLine Citation:
PMID:  2327966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have examined the effects of starvation, normal lab chow and low-fat carbohydrate-rich diet on rat fatty acid synthase (FAS, EC 2.3.1.85). Under each of the dietary conditions the amount of FAS mRNA is different, the most being produced after a low-fat carbohydrate-rich diet. There is also an increase in the amount of FAS protein under the same conditions. To complete the picture we determined the incorporation of [14C]acetate into palmitate as a measure of enzyme activity. Data for cardiac and renal tissue also reflect a dietary influence on FAS. Therefore FAS mRNA, FAS protein and FAS activity are all responsive to dietary-induced signals, and our results suggest a pre-translational regulation.
Authors:
T Laux; M Schweizer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  266     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-05-14     Completed Date:  1990-05-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  793-7     Citation Subset:  IM    
Affiliation:
Institut für Mikrobiologie und Biochemie, Universität Erlangen-Nürnberg, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Diet*
Fatty Acid Synthetase Complex / biosynthesis,  genetics*
Gene Expression Regulation, Enzymologic*
Kidney / enzymology,  metabolism
Liver / enzymology,  metabolism*
Male
Myocardium / enzymology,  metabolism
Protein Biosynthesis
RNA, Messenger / metabolism
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/RNA, Messenger; EC 6.-/Fatty Acid Synthetase Complex
Comments/Corrections

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