Document Detail

Dietary implications on mechanisms of sarcopenia: roles of protein, amino acids and antioxidants.
MedLine Citation:
PMID:  19800212     Owner:  NLM     Status:  MEDLINE    
Sarcopenia, the age-related loss of muscle mass and strength, is a fundamental cause of frailty, functional decline and disability. In the year 2000, $18.5 billion in health care costs were directly attributable to sarcopenia. This economic burden will increase dramatically as the elderly population grows over the next decade. The primary causes of sarcopenia include a sedentary lifestyle and malnutrition. While resistance training appears to be a promising intervention, older individuals exhibit a blunted hypertrophic response to exercise stimuli. It has been posited that this decrement in regenerative capacity may be due to the loss of postprandial anabolism as well as an increase in reactive oxygen species. As such, a combination of resistance training and nutritional interventions may be a promising candidate in combating sarcopenia. Nevertheless, the mechanisms by which the manipulation of dietary variables may improve the sarcopenic condition are not well understood. To address this gap in extant knowledge, this review will examine the effects of protein, amino acid and/or antioxidant intake on sarcopenia both at rest and following resistance training exercise.
Jeong-Su Kim; Jacob M Wilson; Sang-Rok Lee
Publication Detail:
Type:  Journal Article; Review     Date:  2009-10-01
Journal Detail:
Title:  The Journal of nutritional biochemistry     Volume:  21     ISSN:  1873-4847     ISO Abbreviation:  J. Nutr. Biochem.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-11-30     Completed Date:  2010-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010081     Medline TA:  J Nutr Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-13     Citation Subset:  IM    
Department of Nutrition, Food and Exercise Sciences, College of Human Sciences, The Florida State University, Tallahassee, FL 32306-1493, USA.
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MeSH Terms
Aged, 80 and over
Aging / physiology
Amino Acids / administration & dosage,  metabolism
Antioxidants / therapeutic use*
Diet / adverse effects*
Dietary Proteins / administration & dosage
Leucine / administration & dosage
Muscle Proteins / metabolism
Muscle, Skeletal / metabolism
Nutritional Requirements
Oxidative Stress / physiology
Protein Biosynthesis / physiology
Resistance Training
Sarcopenia / etiology*,  physiopathology
Sedentary Lifestyle
Reg. No./Substance:
0/Amino Acids; 0/Antioxidants; 0/Dietary Proteins; 0/Muscle Proteins; 61-90-5/Leucine

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