Document Detail

Dietary hyperphagia in rats: role of fat, carbohydrate, and energy content.
MedLine Citation:
PMID:  2168565     Owner:  NLM     Status:  MEDLINE    
Dietary energy, fat and carbohydrate content were varied to determine the nutritional factors responsible for hyperphagia induced by feeding rats high-fat diets. In the first experiment, rats were fed isoenergetic high-fat or high-carbohydrate diets for 2 weeks. Weight gain and energy intake were lower in rats given the high-fat diet. When some of the rats were switched to a diet that was high in fat, carbohydrate and energy, gram food intake was initially unchanged, resulting in a substantial increase in energy intake and weight gain. Energy intake gradually declined over the 4 weeks following the switch to the high-energy diet. In the second experiment, rats were fed high-fat diets that were either high or low in carbohydrate content and either high or low in energy content (kcal/g). Rats fed a high-fat diet that was high in energy and carbohydrate ate the most energy and gained the most body weight and carcass fat. In the third experiment, rats were fed high-carbohydrate diets varying in fat and cellulose content. Energy intake and body weight gain varied directly as a function of caloric density regardless of the fat or cellulose content of the diets. It is concluded that hyperphagia induced by feeding high-fat diets is not due to the high dietary fat content alone. Rather, high levels of fat, carbohydrate, and energy interact to produce overeating and obesity in rats fed high-fat diets.
I Ramirez; M I Friedman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  47     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-10-05     Completed Date:  1990-10-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1157-63     Citation Subset:  IM    
Monell Chemical Senses Center, Philadelphia, PA 19104-3308.
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MeSH Terms
Body Composition / physiology
Body Weight / physiology*
Dietary Carbohydrates / administration & dosage*
Dietary Fats / administration & dosage*
Dietary Fiber / administration & dosage
Energy Intake / physiology*
Energy Metabolism / physiology*
Feeding Behavior / physiology*
Grant Support
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats

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