| Dietary glycemic index, dietary glycemic load, blood lipids, and C-reactive protein. | |
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MedLine Citation:
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PMID: 18249220 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carbohydrate quantity and quality may influence the risk of cardiovascular disease through blood lipid concentrations and inflammation. We measured dietary glycemic index (GI) and dietary glycemic load (GL) among 18137 healthy women > or = 45 years old without diagnosed diabetes using a food-frequency questionnaire. We assayed fasting total, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol; LDL/HDL cholesterol ratio; triacylglycerols (TG); and C-reactive protein (CRP). We evaluated associations with dietary GI and GL using a cross-sectional design, adjusting for age, body mass index, lifestyle factors, and other dietary factors. Dietary GI was significantly associated with HDL and LDL cholesterol, LDL/HDL cholesterol ratio, TG, and CRP (comparing top to bottom quintile difference in HDL cholesterol = -2.6 mg/dL, LDL cholesterol = 2.2 mg/dL, LDL/HDL cholesterol ratio = 0.16, TG = 12 mg/dL, and CRP = 0.21 mg/L). Dietary GL was associated with HDL cholesterol, LDL/HDL cholesterol ratio, and TG (comparing top to bottom quintile HDL cholesterol = -4.9 mg/dL, LDL/HDL cholesterol ratio = 0.24, and TG = 13 mg/dL). Differences in blood lipids and CRP between extreme quintiles of dietary GI and GL were small, but may translate into a clinically meaningful difference in cardiovascular risk. |
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Authors:
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Emily B Levitan; Nancy R Cook; Meir J Stampfer; Paul M Ridker; Kathryn M Rexrode; Julie E Buring; JoAnn E Manson; Simin Liu |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 57 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-05 Completed Date: 2008-03-11 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 437-43 Citation Subset: IM |
Affiliation:
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Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. elevitan@bidmc.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers Body Mass Index C-Reactive Protein / metabolism* Cross-Sectional Studies Diet* Estrogen Replacement Therapy Exercise Female Glucose / pharmacology* Glycemic Index / physiology* Humans Hypertension / epidemiology Lipids / blood* Middle Aged Questionnaires |
| Grant Support | |
ID/Acronym/Agency:
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CA47988/CA/NCI NIH HHS; HL 7374/HL/NHLBI NIH HHS; HL43851/HL/NHLBI NIH HHS; R01 CA047988-17/CA/NCI NIH HHS; R01 HL043851-10/HL/NHLBI NIH HHS; T32 HL007374-29/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Lipids; 50-99-7/Glucose; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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