| Dietary glutamine suppresses endogenous glutamine turnover in the rat. | |
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MedLine Citation:
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PMID: 10647078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma glutamine turnover was determined using 1-14C-labeled glutamine in rats that consumed crystalline amino acid diets containing the equivalent of 16% protein with 25% of the amino acids as glutamine or a control diet containing no glutamine (or glutamate) for 10 days. Glutamine turnover in glutamine-fed animals was 66% of the rate in the control group. Glutamine feeding caused 20% higher levels of arterial plasma glutamine. Arterial-portal differences across the portal-drained viscera showed net glutamine uptake in control animals but no net uptake or release in the glutamine-fed group. Skeletal muscle glutamine synthetase activity was similar in both groups. The results indicate that long-term consumption of relatively large amounts of dietary glutamine decreases the turnover of plasma glutamine and thus reduces the need for endogenous glutamine synthesis. |
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Authors:
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M Watford; B Darcy-Vrillon; P H Duée |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 49 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-02-02 Completed Date: 2000-02-02 Revised Date: 2010-01-29 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 141-5 Citation Subset: IM |
Affiliation:
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Department of Nutritional Sciences, Cook College, Rutgers University, New Brunswick, NJ 08901-8525, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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blood Animals Diet Down-Regulation Glutamine / administration & dosage, metabolism, pharmacology* Male Muscle, Skeletal / metabolism Proteins / metabolism Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Proteins; 56-85-9/Glutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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