Document Detail

Dietary glutamine supplementation reduces plasma nitrate levels in rats.
MedLine Citation:
PMID:  10205309     Owner:  NLM     Status:  MEDLINE    
It was recently shown that L-glutamine inhibits vascular nitric oxide (NO) production in vitro. The present study investigated the effect of glutamine enriched enteral diets on in vivo NO production in the rat. Nitrate, the stable end-product of NO production, was measured in plasma and 24 h urine collections in glutamine supplemented rats (6.25%, 12.5% and 25% w/w) and compared to the effect of isocaloric, nitrogenous control diets. Glutamine supplementation increased plasma levels of glutamine (up to 91%), arginine (up to 17%) and citrulline (up to 54%). After 1 week of glutamine supplementation plasma nitrate levels were significantly reduced by 50% compared to control (P < 0. 0001); irrespective of the amount of supplementation. No further decrease was observed after 2 weeks of feeding. No differences in daily urinary losses were found between the groups. These results point to an in vivo inhibitory effect of glutamine supplemented enteral feeding on NO production.
A P Houdijk; J J Visser; E R Rijnsburger; T Teerlink; P A van Leeuwen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  17     ISSN:  0261-5614     ISO Abbreviation:  Clin Nutr     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1999-04-30     Completed Date:  1999-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  11-4     Citation Subset:  IM    
Department of Surgery and Clinical Chemistry, Free University Hospital, Amsterdam, The Netherlands.
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MeSH Terms
Arginine / blood
Citrulline / blood
Dietary Supplements*
Glutamine / administration & dosage*,  blood
Nitrates / blood*
Rats, Inbred F344
Reg. No./Substance:
0/Nitrates; 372-75-8/Citrulline; 56-85-9/Glutamine; 74-79-3/Arginine
Comment In:
Clin Nutr. 1998 Feb;17(1):1-2   [PMID:  10232923 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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