Document Detail

Dietary gangliosides enhance in vitro lipid uptake in weanling rats.
MedLine Citation:
PMID:  16385255     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The intestine adapts morphologically or functionally in response to environmental stimuli. Dietary lipids modify brush border membrane (BBM) permeability and nutrient transporter activities. Gangliosides (GANG) are glycolipids in human milk that are present only in low amounts in infant formula. Exogenous GANG are incorporated into cell membranes and increase their permeability. The objective of this study was to determine whether feeding a GANG-enriched diet alters in vitro intestinal lipid absorption. METHODS: Weanling rats were fed either (1) GANG-enriched diet; (2) diet enriched with polyunsaturated long-chain fatty acids; or (3) isocaloric control diet for 2 weeks, after which in vitro intestinal lipid uptake was measured. RESULTS: Feeding GANG did not alter weight gain or intestinal morphology. Enhanced uptake of stearic acid (18:0) in the ileum and stearic and linoleic acid (18:2) in the jejunum was not associated with a change in the abundance of the ileal lipid binding protein (ILBP), the intestinal fatty acid binding protein (I-FABP), or the liver fatty acid binding protein (L-FABP). CONCLUSION: We speculate that the enhanced uptake of long-chain fatty acids in weanling rats fed GANG may be caused by a modification in physical properties of the BBM.
Celina J Birecki; Laurie A Drozdowski; Miyoung Suh; Eek Joong Park; M Tom Clandinin; Alan B R Thomson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  42     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-30     Completed Date:  2006-06-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-65     Citation Subset:  IM    
Nutrition and Metabolism Group, Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
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MeSH Terms
Adaptation, Physiological
Body Weight / drug effects
Fatty Acid-Binding Proteins
Fatty Acids, Unsaturated / administration & dosage,  metabolism*
Gangliosides / administration & dosage,  metabolism*
Ileum / drug effects,  metabolism,  pathology
Intestinal Absorption
Intestine, Small / drug effects*,  metabolism,  pathology
Jejunum / drug effects,  metabolism,  pathology
Lipid Metabolism / drug effects*,  physiology
Microvilli / physiology*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Fatty Acid-Binding Proteins; 0/Fatty Acids, Unsaturated; 0/Gangliosides

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