| Dietary gamma-linolenic acid in the form of borage oil causes less body fat accumulation accompanying an increase in uncoupling protein 1 mRNA level in brown adipose tissue. | |
| | |
MedLine Citation:
|
PMID: 11079375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Rats were fed a low-fat diet containing 2% safflower oil or 20% fat diets containing either safflower oil rich in linoleic acid, borage oil containing 25% gamma (gamma)-linolenic acid or enzymatically prepared gamma-linolenic acid enriched borage oil containing 47% gamma-linolenic acid for 14 days. Energy intake and growth of animals were the same among groups. A high safflower oil diet compared with a low-fat diet caused significant increases in both epididymal and perirenal white adipose tissue weights. However, high-fat diets rich in gamma-linolenic acid failed to do so. Compared with a low-fat diet, all the high-fat diets increased mRNA levels of uncoupling protein 1 and lipoprotein lipase in brown adipose tissue. The extents of the increase were greater with high-fat diets rich in gamma-linolenic acid. Various high-fat diets, compared with a low-fat diet, decreased glucose transporter 4 mRNA in white adipose tissue to the same levels. The amount and types of dietary fat did not affect the leptin mRNA level in epididymal white adipose tissue. However, a high safflower oil diet, but not high-fat diets rich in gamma-linolenic acid relative to a low-fat diet, increased perirenal white adipose tissue leptin mRNA levels. All high-fat diets, relative to a low-fat diet, increased the hepatic mitochondrial fatty acid oxidation rate and fatty acid oxidation enzyme mRNA abundances to the same levels. High-fat diets also increased these parameters in the peroxisomal pathway, and the increases were greater with high-fat diets rich in gamma-linolenic acid. The physiological activity in increasing brown adipose tissue gene expression and peroxisomal fatty acid oxidation was similar between the two types of borage oil differing in gamma-linolenic acid content. It was suggested that dietary gamma-linolenic acid attenuates body fat accumulation through the increase in gene expressions of uncoupling protein 1 in brown adipose tissue. An increase in hepatic peroxisomal fatty acid oxidation may also contribute to the physiological activity of gamma-linolenic acid in decreasing body fat mass. |
| | |
Authors:
|
Y Takahashi; T Ide; H Fujita |
Related Documents
:
|
16872345 - Facts on fats. 21127345 - Fasting-induced reductions in cardiovascular and metabolic variables occur sooner in ob... 8215235 - Dietary diacylglycerol-dependent reduction in serum triacylglycerol concentration in rats. 9497165 - Diet effects on fatty acid metabolism in lean and obese humans. 22720935 - Ovariectomy improves lactation persistency in dairy cows. 21126585 - Inhibition of p38 mapk during cellular activation modulate gene expression of head kidn... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology Volume: 127 ISSN: 1096-4959 ISO Abbreviation: Comp. Biochem. Physiol. B, Biochem. Mol. Biol. Publication Date: 2000 Oct |
Date Detail:
|
Created Date: 2001-02-05 Completed Date: 2001-03-01 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9516061 Medline TA: Comp Biochem Physiol B Biochem Mol Biol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 213-22 Citation Subset: IM |
Affiliation:
|
Laboratory of Nutrition Biochemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba Science City, Ibaraki, Japan. youkot@nfri.affrc.go.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue
/
metabolism Adipose Tissue, Brown / drug effects*, metabolism Animals Carrier Proteins / biosynthesis* Diet Diet, Fat-Restricted Fatty Acids / metabolism Ion Channels Leptin / metabolism Lipoprotein Lipase / metabolism Liver / enzymology Male Membrane Proteins / biosynthesis* Mitochondria / metabolism Mitochondrial Proteins Monosaccharide Transport Proteins / metabolism Oxygen / metabolism Palmitoyl Coenzyme A / metabolism Peroxisomes / metabolism Plant Oils / pharmacology* RNA, Messenger / metabolism* Rats Safflower Oil / pharmacology gamma-Linolenic Acid / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Carrier Proteins; 0/Fatty Acids; 0/Ion Channels; 0/Leptin; 0/Membrane Proteins; 0/Mitochondrial Proteins; 0/Monosaccharide Transport Proteins; 0/Plant Oils; 0/RNA, Messenger; 0/borage oil; 0/mitochondrial uncoupling protein; 1763-10-6/Palmitoyl Coenzyme A; 506-26-3/gamma-Linolenic Acid; 7782-44-7/Oxygen; 8001-23-8/Safflower Oil; EC 3.1.1.34/Lipoprotein Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effects of salinity on the interaction between a pathogen (Listonella anguillarum) and component...
Next Document: Cloning of a neonatal calcium atpase isoform (SERCA 1B) from extraocular muscle of adult blue marlin...