Document Detail

Dietary gallate esters of tea catechins reduce deposition of visceral fat, hepatic triacylglycerol, and activities of hepatic enzymes related to fatty acid synthesis in rats.
MedLine Citation:
PMID:  15914933     Owner:  NLM     Status:  MEDLINE    
Tea catechins, rich in (-)-epigallocatechin gallate and (-)-epicatechin gallate, or heat-treated tea catechins in which about 50% of the (-)-epigallocatechin gallate and (-)-epicatechin gallate in tea catechins was epimerized to (-)-gallocatechin gallate and (-)-catechin gallate, were fed to rats at 1% level for 23 d. Visceral fat deposition and the concentration of hepatic triacylglycerol were significantly lower in the tea catechin and heat-treated tea catechin groups than in the control group. The activities of fatty acid synthase and the malic enzyme in the liver cytosol were significantly lower in the two catechin groups than in the control group. In contrast, the activities of carnitine palmitoyltransferase and acyl-CoA oxidase in the liver homogenate were not significantly different among the three groups. These results suggest that the reduction in activities of enzymes related to hepatic fatty acid synthesis by the feeding of tea catechins or heat-treated tea catechins can cause reductions of hepatic triacylglycerol and possibly of visceral fat deposition.
Ikuo Ikeda; Reina Hamamoto; Kazunori Uzu; Katsumi Imaizumi; Koji Nagao; Teruyoshi Yanagita; Yuko Suzuki; Makoto Kobayashi; Takami Kakuda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  69     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-25     Completed Date:  2005-09-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1049-53     Citation Subset:  IM    
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Adipose Tissue / drug effects
Anti-Obesity Agents / pharmacology*
Antioxidants / pharmacology
Catechin / analogs & derivatives*,  pharmacology
Fatty Acid Synthetase Complex / metabolism
Fatty Acids / biosynthesis
Gallic Acid / analogs & derivatives*,  pharmacology
Liver / drug effects,  metabolism
Rats, Sprague-Dawley
Tea / chemistry*
Triglycerides / metabolism
Reg. No./Substance:
0/Anti-Obesity Agents; 0/Antioxidants; 0/Fatty Acids; 0/Tea; 0/Triglycerides; 0/epigallocatecol gallate; 149-91-7/Gallic Acid; 154-23-4/Catechin; 863-03-6/epicatechin gallate; EC 6.-/Fatty Acid Synthetase Complex

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