| Dietary fructo-oligosaccharides improve insulin sensitivity along with the suppression of adipocytokine secretion from mesenteric fat cells in rats. | |
| | |
MedLine Citation:
|
PMID: 21736797 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Short-chain fructo-oligosaccharides (FOS) are known to have beneficial effects on health. However, the effects of FOS on insulin resistance have not been fully clarified. We observed the effects of FOS feeding on insulin sensitivity and adipocytokine release from abdominal adipocytes in weaning rats. Male Sprague-Dawley rats, 3 weeks old, were divided into three groups and fed a sucrose-based American Institute of Nutrition (AIN)-93 growth diet (control), the control diet containing 5 % FOS for 5 weeks (FOS-5wk) or the control diet for 2 weeks followed by the 5 % FOS diet for 3 weeks (FOS-3wk). Tail blood was collected after fasting for 9 h on day 33 of feeding, and glucose and insulin levels were measured. On the last day, rats were anaesthetised and killed after the collection of aortic blood. Small- and large-intestinal mesenteric fat tissues were immediately excised, and the release of adiponectin, leptin and TNF-α was evaluated from the subsequently isolated adipocytes. The weight of the large-intestinal mesenteric fat, fasting blood insulin level and homeostatic model assessment for insulin resistance decreased in a time-dependent manner, and were much lower in the FOS-5wk group than in the control group. These values were correlated with aortic blood leptin levels. The secretion rate of leptin from the isolated mesenteric adipocytes in the small intestine, but not in the large intestine, was lower in the FOS-fed groups than in the control group. In conclusion, FOS feeding improved insulin sensitivity accompanied by the reduction in large-intestinal fat mass and leptin secretion from the mesenteric adipocytes of the small intestine. |
| | |
Authors:
|
Aki Shinoki; Hiroshi Hara |
Related Documents
:
|
20046857 - A historical perspective of the understanding of the link between diet and coronary hea... 17172277 - The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative str... 7427547 - Effect of treatment of hyperlipidaemia on haemostatic variables. 16549487 - Reducing hypertensive cardiovascular disease risk of african americans with diet: focus... 20132047 - Combination of genistin and fructooligosaccharides prevents bone loss in ovarian hormon... 19484707 - Effects of soy vs. casein protein on body weight and glycemic control in female monkeys... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-2 |
Journal Detail:
|
Title: The British journal of nutrition Volume: - ISSN: 1475-2662 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-7-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: - |
Other Details:
|
Languages: ENG Pagination: 1-8 Citation Subset: - |
Affiliation:
|
Division of Applied Bioscience, Laboratory of Nutritional Biochemistry, Research Faculty of Agriculture, Hokkaido University, Kita-9, Nishi-9, Kita-ku, Sapporo 060-8589, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of Nori- and Wakame-enriched meats with or without supplementary cholesterol on arylesterase...
Next Document: Accounting for the multidimensional nature of the relationship between adult obesity and socio-econo...