| Dietary free glutamate prevents diarrhoea during intra-gastric tube feeding in a rat model. | |
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MedLine Citation:
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PMID: 21733333 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Recent studies indicate that l-glutamate (l-Glu), abundant in many foods, is a stimulator of gastric vagal afferent nerves. The aim of the present study was to examine the possibility that l-Glu supplementation of a protein-rich liquid diet may prevent the incidence of diarrhoea during repetitive intra-gastric tube feeding. The gastric vagal afferent nerve recording of rats indicated that intra-gastric administration of a protein-rich liquid diet supplemented with 0·5 % monosodium glutamate enhanced the basal afferent activities seen with the protein-rich diet alone. The examination of the faeces showed that the addition of monosodium glutamate to the liquid diet significantly prevented the incidence of diarrhoea induced by repetitive gastric feeding. In conclusion, supplementation of an enteral liquid diet with free l-Glu may ameliorate diarrhoea during intra-gastric tube feeding by sending visceral glutamate information from the stomach to the brain. |
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Authors:
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Shinji Somekawa; Naoki Hayashi; Akira Niijima; Hisayuki Uneyama; Kunio Torii |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-24 |
Journal Detail:
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Title: The British journal of nutrition Volume: - ISSN: 1475-2662 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-7-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: - |
Other Details:
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Languages: ENG Pagination: 1-4 Citation Subset: - |
Affiliation:
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Institute for Innovation, Ajinomoto Company, Inc., 210-8681 Kanagawa, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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