| Dietary fish oil and curcumin combine to modulate colonic cytokinetics and gene expression in dextran sodium sulphate-treated mice. | |
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MedLine Citation:
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PMID: 21401974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Both fish oil (FO) and curcumin have potential as anti-tumour and anti-inflammatory agents. To further explore their combined effects on dextran sodium sulphate (DSS)-induced colitis, C57BL/6 mice were randomised to four diets (2 × 2 design) differing in fatty acid content with or without curcumin supplementation (FO, FO+2 % curcumin, maize oil (control, MO) or MO+2 % curcumin). Mice were exposed to one or two cycles of DSS in the drinking-water to induce either acute or chronic intestinal inflammation, respectively. FO-fed mice exposed to the single-cycle DSS treatment exhibited the highest mortality (40 %, seventeen of forty-three) compared with MO with the lowest mortality (3 %, one of twenty-nine) (P = 0·0008). Addition of curcumin to MO increased (P = 0·003) mortality to 37 % compared with the control. Consistent with animal survival data, following the one- or two-cycle DSS treatment, both dietary FO and curcumin promoted mucosal injury/ulceration compared with MO. In contrast, compared with other diets, combined FO and curcumin feeding enhanced the resolution of chronic inflammation and suppressed (P < 0·05) a key inflammatory mediator, NF-κB, in the colon mucosa. Mucosal microarray analysis revealed that dietary FO, curcumin and FO plus curcumin combination differentially modulated the expression of genes induced by DSS treatment. These results suggest that dietary lipids and curcumin interact to regulate mucosal homeostasis and the resolution of chronic inflammation in the colon. |
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Authors:
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Qian Jia; Ivan Ivanov; Zlatomir Z Zlatev; Robert C Alaniz; Brad R Weeks; Evelyn S Callaway; Jennifer S Goldsby; Laurie A Davidson; Yang-Yi Fan; Lan Zhou; Joanne R Lupton; David N McMurray; Robert S Chapkin |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-03-15 |
Journal Detail:
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Title: The British journal of nutrition Volume: 106 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-02 Completed Date: 2011-09-29 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 519-29 Citation Subset: IM |
Affiliation:
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Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, TX, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Anti-Inflammatory Agents, Non-Steroidal / adverse effects, therapeutic use Chronic Disease Colitis / diet therapy*, immunology, metabolism, pathology Colon / drug effects, immunology, metabolism*, pathology Curcumin / adverse effects, therapeutic use* Cytokines / genetics, metabolism* Dextran Sulfate / administration & dosage, toxicity Dietary Supplements* Fish Oils / adverse effects, therapeutic use* Gene Expression Profiling Gene Expression Regulation* Intestinal Mucosa / drug effects, immunology, metabolism, pathology Irritants / administration & dosage, toxicity Male Mice Mice, Inbred C57BL NF-kappa B / genetics, metabolism Oligonucleotide Array Sequence Analysis Random Allocation Survival Analysis |
| Grant Support | |
ID/Acronym/Agency:
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CA129444/CA/NCI NIH HHS; CA59034/CA/NCI NIH HHS; DK071707/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cytokines; 0/Fish Oils; 0/Irritants; 0/NF-kappa B; 458-37-7/Curcumin; 9042-14-2/Dextran Sulfate |
| Comments/Corrections | |
Comment In:
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Br J Nutr. 2011 Dec;106(11):1763; author reply 1764
[PMID:
21933457
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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