Document Detail


Dietary fish oil administration retards blood pressure development and influences vascular properties in the spontaneously hypertensive rat (SHR) but not in the stroke prone-spontaneously hypertensive rat (SHR-SP).
MedLine Citation:
PMID:  8199712     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, we compared the blood pressure in the SHR-SP and in the spontaneously hypertensive rat (SHR) after dietary administration of fish oil from 4 to 17 weeks of age. The retarding influence of dietary fish oils on the development of hypertension was prominent in the SHR (26 mmHg) and not evident in the SHR-SP (8 mmHg). The enhanced development of blood pressure in both the SHR and the SHR-SP is characterised by an elevated maximum contraction in the mesenteric vascular bed to sympathetic nerve stimulation and to injected noradrenaline. In SHR, but not SHR-SP, this maximum contraction was significantly attenuated by dietary fish oil. Likewise, acetylcholine mediated relaxation of the isolated aorta was enhanced in preparations from the SHR but not the SHR-SP. These physiological changes were also associated with a change in the total n-3 polyunsaturated fatty acids (PUFAs) content in vascular tissue, which were inversely proportional to the prevailing blood pressure values seen in all three strains of rat receiving dietary fish oils. Platelet activated thromboxane production was equally depressed in WKY (Wistar Kyoto), SHR and SHR-SP rats. The results indicate that the blood pressure lowering effect of fish oil when administered during the period of development of hypertension is much greater in the SHR than it is in the SHR-SP. Furthermore the lowering of blood pressure by fish oil administration is related to a restoration of normal vascular contraction and normal vascular relaxation, but not related to a suppression of serum thromboxane production.
Authors:
S Bexis; Y K Lungershausen; M T Mano; P R Howe; J Q Kong; D L Birkle; D A Taylor; R J Head
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood pressure     Volume:  3     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-01     Completed Date:  1994-07-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  120-6     Citation Subset:  IM    
Affiliation:
CSIRO Division of Human Nutrition, Adelaide, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / metabolism
Blood Pressure / drug effects*
Blood Vessels / drug effects*,  metabolism
Body Weight / drug effects
Dietary Fats, Unsaturated / pharmacology*
Fatty Acids / metabolism
Fish Oils / pharmacology*
Genetic Predisposition to Disease
Male
Mesenteric Arteries / drug effects,  innervation
Rats
Rats, Inbred SHR / genetics,  physiology*
Rats, Inbred WKY
Vasoconstriction / drug effects
Grant Support
ID/Acronym/Agency:
GM 29840/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids; 0/Fish Oils

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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