| Dietary fibre consumption and insulin resistance - the role of body fat and physical activity. | |
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MedLine Citation:
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PMID: 23218116 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The present study was conducted to determine the association between fibre intake and insulin resistance in 264 women using a cross-sectional design. Insulin resistance was indexed using homeostasis model assessment of insulin resistance (HOMA-IR) (US formula: fasting insulin (μU/ml) × fasting glucose (mg/dl)/405 international formula: fasting glucose (mmol/l) × fasting insulin (μU/l)/22.5). Fibre and energy consumption were assessed using 7 d weighed food records. Fibre was expressed as g/4184 kJ (1000 kcal). Body fat percentage (BF%) was measured using the BOD POD, and physical activity (PA) was ascertained using Actigraph accelerometers (Health One Technology) worn for seven consecutive days. Women with high total fibre intakes (F = 4·58, P = 0·0332) or high soluble fibre intakes (F = 7·97, P = 0·0051) had significantly less insulin resistance than their counterparts. Participants with high insoluble fibre intakes did not differ from their counterparts (F = 0·7, P = 0·6875). Adjusting for either PA or BF% weakened the relationships significantly. Controlling for BF% nullified the total fibre-HOMA-IR link (F = 1·96, P = 0·1631) and attenuated the association between soluble fibre and HOMA-IR by 32 % (F = 6·86, P = 0·0094). To create dichotomous variables, fibre intake and HOMA-IR were each divided into two categories using the median (low and high). In women who had high soluble fibre intake (upper 50 %), the OR of having an elevated HOMA-IR level was 0·58 (95 % CI 0·36, 0·94) times that of women with low soluble fibre intake (lower 50 %). After controlling for all of the potential confounding factors simultaneously, the OR was 0·52 (95 % CI 0·29, 0·93). High fibre intake, particularly soluble fibre, is significantly related to lower levels of insulin resistance in women. Part of this association is a function of differences in PA and BF%. |
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Authors:
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Charity B Breneman; Larry Tucker |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-7 |
Journal Detail:
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Title: The British journal of nutrition Volume: - ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: - |
Other Details:
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Languages: ENG Pagination: 1-9 Citation Subset: - |
Affiliation:
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Department of Exercise Sciences, Brigham Young University, Provo, Utah 84602, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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