| Dietary fibers reduce food intake by satiation without conditioned taste aversion in mice. | |
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MedLine Citation:
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PMID: 23268328 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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It is well known that intake of dietary fibre (DF) potently decreases food intake and feelings of hunger and/or promotes satiety ratings. However, the mechanisms explaining these effects are not well characterized. This work was performed to determine which of satiation and/or satiety mechanisms provoke the decrease of food intake induced by DF in mice. We tested in an intra-group protocol a low-viscosity (LV, fructo-oligosaccharide), a viscous (VP, guar gum) and a high-viscosity preload (HV, mixture of guar gum and fructo-oligosaccharide) preload. These were given to mice by intra-gastric gavage. It appeared that viscous preloads such as VP and HV reduced the daily energy intake by 14% and 21% respectively. The strong effect of HV was mainly due to a large decrease of meal size (by 57 %) and meal duration (by 65%) with no effect on ingestion rate during the first 30 min after administration. Therefore, the DF- induced decrease of energy intake was due to a satiation mechanism. This is further supported by a 3-fold increased sensitization of neurons in the nucleus of the solitary tract as observed by c-Fos protein immunolabelling. No compensation of food intake was observed during the rest of the day, a phenomenon that may be explained by the fact that metabolic rate remained high despite the lower food intake. We have also shown that the DF-induced inhibition of food intake was not paired with a conditioned taste aversion. To conclude, this work demonstrates that DF inhibits food intake by increasing satiation during ~1 hour after administration. |
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Authors:
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Rojo Rasoamanana; Patrick C Even; Nicolas Darcel; Daniel Tomé; Gilles Fromentin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-22 |
Journal Detail:
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Title: Physiology & behavior Volume: - ISSN: 1873-507X ISO Abbreviation: Physiol. Behav. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
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AgroParisTech, CRNH-IdF, UMR 914 Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France; INRA, CRNH-IdF, UMR 914 Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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