Document Detail


Dietary fiber intake and retinal vascular caliber in the Atherosclerosis Risk in Communities Study.
MedLine Citation:
PMID:  18065579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Dietary fiber appears to decrease the risk of cardiovascular morbidity and mortality. Microvascular abnormalities can be observed by retinal examination and contribute to the pathogenesis of various cardiovascular diseases. The impact of dietary fiber on the retinal microvasculature is not known. OBJECTIVE: We aimed to examine the association between dietary fiber intake and retinal vascular caliber. DESIGN: At the third visit (1993-1995) of the Atherosclerosis Risk in Communities (ARIC) Study, a population-based cohort of adults in 4 US communities, the retinal vascular caliber of 10,659 participants was measured and summarized from digital retinal photographs. Usual dietary intake during the same period was assessed with a 66-item food-frequency questionnaire. RESULTS: After control for potential confounders including hypertension, diabetes, lipids, demographic factors, cigarette smoking, total energy intake, micronutrients intake, and other cardiovascular disease risk factors, higher intake of fiber from all sources and from cereal were significantly associated with wider retinal arteriolar caliber and narrower venular caliber. Participants in the highest quintile of fiber intake from all sources had a 1.05-microm larger arteriolar caliber (P for trend = 0.012) and a 1.11-microm smaller venular caliber (P for trend = 0.029). CONCLUSIONS: Dietary fiber was related to wider retinal arteriolar caliber and narrower venular caliber, which are associated with a lower risk of cardiovascular disease. These data add to the growing evidence of the benefits of fiber intake on various aspects of cardiovascular pathogenesis.
Authors:
Haidong Kan; June Stevens; Gerardo Heiss; Ronald Klein; Kathryn M Rose; Stephanie J London
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  86     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-10     Completed Date:  2008-01-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1626-32     Citation Subset:  AIM; IM    
Affiliation:
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
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MeSH Terms
Descriptor/Qualifier:
Arterioles / anatomy & histology,  drug effects
Blood Pressure / physiology
Cardiovascular Diseases / pathology*,  prevention & control
Cholesterol / blood
Cohort Studies
Dietary Fiber / administration & dosage*
Female
Humans
Linear Models
Male
Middle Aged
Multivariate Analysis
Retinal Artery / anatomy & histology,  drug effects*
Retinal Vein / anatomy & histology,  drug effects*
Triglycerides / blood
United States / epidemiology
Grant Support
ID/Acronym/Agency:
N01 HC55015/HC/NHLBI NIH HHS; N01 HC55016/HC/NHLBI NIH HHS; N01 HC55018/HC/NHLBI NIH HHS; N01 HC55019/HC/NHLBI NIH HHS; N01 HC55020/HC/NHLBI NIH HHS; N01 HC55021/HC/NHLBI NIH HHS; N01 HC55022/HC/NHLBI NIH HHS; Z01 ES043012/ES/NIEHS NIH HHS; Z01 ES043012-09/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Triglycerides; 57-88-5/Cholesterol
Comments/Corrections

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