| Dietary fatty acids and peripheral artery disease in adults. | |
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MedLine Citation:
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PMID: 22552117 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Peripheral artery disease (PAD) is a debilitating condition involving atherosclerosis. Although saturated, monounsaturated and polyunsaturated fatty acids have strong associations with atherosclerosis, it is unclear if diets high in these fatty acids affect PAD. METHODS: We studied 6352 adults aged 40 years and older who participated in the U.S. National Health and Nutrition Examination Survey between 1999 and 2004. Ankle brachial index (ABI) was assessed by standardized blood pressure measurements, and we defined PAD as an ABI<0.9. Fatty acid intake was assessed by validated 24-h dietary recall. We used multivariable linear and logistic regression to estimate associations between intakes of dietary saturated fatty acids (SFAs), monounsaturated fatty acids (MFAs), marine omega-3 fatty acids (N-3), linolenic acid (LNA), and omega-6 fatty acids (N-6) and ABI/PAD. RESULTS: The prevalence and 95% confidence interval (CI) of PAD was 5.2% (95% CI 4.6-5.8). There were no associations between ABI and intakes of marine N-3 (p=0.83) or N-6 (p=0.19) in adjusted models. In contrast, LNA was associated with higher ABI (p=0.04) and SFA tended to be associated with lower ABI (p=0.06) in adjusted models. In addition, higher SFA was associated with a higher prevalence of PAD: adjusted odds ratio 1.30 (95% CI 1.01-1.67; p=0.04) and a trend toward slower gait speed (p=0.08). CONCLUSION: In this nationally representative sample, higher dietary intakes of LNA and SFAs were associated with higher and lower ABI, respectively. Prospective studies are needed to confirm the potential protective effects of dietary LNA and detrimental effects of dietary SFAs on PAD. |
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Authors:
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Asghar Z Naqvi; Roger B Davis; Kenneth J Mukamal |
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Publication Detail:
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Type: Journal Article Date: 2012-04-07 |
Journal Detail:
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Title: Atherosclerosis Volume: 222 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-28 Completed Date: 2012-09-20 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 545-50 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Harvard Medical School, Boston, MA, USA. asghar_naqvi@hms.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Ankle Brachial Index Blood Pressure Cross-Sectional Studies Dietary Fats / administration & dosage* Fatty Acids / administration & dosage* Fatty Acids, Monounsaturated / administration & dosage Fatty Acids, Omega-3 / administration & dosage Female Humans Linear Models Linoleic Acid / administration & dosage Logistic Models Male Middle Aged Multivariate Analysis Nutrition Surveys Odds Ratio Peripheral Arterial Disease / diagnosis, epidemiology*, physiopathology, prevention & control Prevalence Risk Assessment Risk Factors United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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T32 AT000051-05/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Omega-3; 2197-37-7/Linoleic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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