Document Detail

Dietary fatty acids and peripheral artery disease in adults.
MedLine Citation:
PMID:  22552117     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Peripheral artery disease (PAD) is a debilitating condition involving atherosclerosis. Although saturated, monounsaturated and polyunsaturated fatty acids have strong associations with atherosclerosis, it is unclear if diets high in these fatty acids affect PAD.
METHODS: We studied 6352 adults aged 40 years and older who participated in the U.S. National Health and Nutrition Examination Survey between 1999 and 2004. Ankle brachial index (ABI) was assessed by standardized blood pressure measurements, and we defined PAD as an ABI<0.9. Fatty acid intake was assessed by validated 24-h dietary recall. We used multivariable linear and logistic regression to estimate associations between intakes of dietary saturated fatty acids (SFAs), monounsaturated fatty acids (MFAs), marine omega-3 fatty acids (N-3), linolenic acid (LNA), and omega-6 fatty acids (N-6) and ABI/PAD.
RESULTS: The prevalence and 95% confidence interval (CI) of PAD was 5.2% (95% CI 4.6-5.8). There were no associations between ABI and intakes of marine N-3 (p=0.83) or N-6 (p=0.19) in adjusted models. In contrast, LNA was associated with higher ABI (p=0.04) and SFA tended to be associated with lower ABI (p=0.06) in adjusted models. In addition, higher SFA was associated with a higher prevalence of PAD: adjusted odds ratio 1.30 (95% CI 1.01-1.67; p=0.04) and a trend toward slower gait speed (p=0.08).
CONCLUSION: In this nationally representative sample, higher dietary intakes of LNA and SFAs were associated with higher and lower ABI, respectively. Prospective studies are needed to confirm the potential protective effects of dietary LNA and detrimental effects of dietary SFAs on PAD.
Asghar Z Naqvi; Roger B Davis; Kenneth J Mukamal
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Publication Detail:
Type:  Journal Article     Date:  2012-04-07
Journal Detail:
Title:  Atherosclerosis     Volume:  222     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-28     Completed Date:  2012-09-20     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  545-50     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Aged, 80 and over
Ankle Brachial Index
Blood Pressure
Cross-Sectional Studies
Dietary Fats / administration & dosage*
Fatty Acids / administration & dosage*
Fatty Acids, Monounsaturated / administration & dosage
Fatty Acids, Omega-3 / administration & dosage
Linear Models
Linoleic Acid / administration & dosage
Logistic Models
Middle Aged
Multivariate Analysis
Nutrition Surveys
Odds Ratio
Peripheral Arterial Disease / diagnosis,  epidemiology*,  physiopathology,  prevention & control
Risk Assessment
Risk Factors
United States / epidemiology
Grant Support
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Omega-3; 9KJL21T0QJ/Linoleic Acid

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