| Dietary fatty acids and insulin resistance. | |
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MedLine Citation:
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PMID: 11122713 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High-fat diets have been associated with insulin resistance, a risk factor for both Type II diabetes and heart disease. The effect of dietary fat on insulin varies depending on the type of fatty acid consumed. Saturated fatty acids have been consistently associated with insulin resistance. On the other hand, medium and long-chain fatty acid intakes are associated with insulin sensitivity, as are high intakes of w3 fatty acids. Trans fatty acids appear to potentiate insulin secretion, at least in the short-term, to a greater degree than cis fatty acids. This may reflect chronic alterations in insulin sensitivity, although this remains to be tested. In summary, although it must be emphasized that all diets high in fat cause insulin resistance relative to high-carbohydrate diets, it appears that dietary saturated, short-chain, and w6 fatty acids have the most deleterious effects on insulin action. |
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Authors:
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J C Lovejoy |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current atherosclerosis reports Volume: 1 ISSN: 1523-3804 ISO Abbreviation: Curr Atheroscler Rep Publication Date: 1999 Nov |
Date Detail:
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Created Date: 2001-01-26 Completed Date: 2001-07-12 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 100897685 Medline TA: Curr Atheroscler Rep Country: United States |
Other Details:
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Languages: eng Pagination: 215-20 Citation Subset: IM |
Affiliation:
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Women's Nutrition Research Program, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808-4124, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Disease
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etiology*,
physiopathology Diabetes Mellitus, Type 2 / etiology Dietary Fats / adverse effects* Fatty Acids / metabolism*, pharmacology Humans Hypoglycemic Agents / pharmacology Insulin / biosynthesis, pharmacology Insulin Resistance* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids; 0/Hypoglycemic Agents; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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