Document Detail

Dietary fatty acids and the glomerular hemodynamic response to cyclosporine in borderline hypertensive rats.
MedLine Citation:
PMID:  7723248     Owner:  NLM     Status:  MEDLINE    
We have recently reported that cyclosporine A (CsA) decreases glomerular filtration rate in the borderline hypertensive rat (BHR), but that the glomerular filtration rate is normal when the rats are maintained on a diet supplemented with evening primrose (EP) oil. The current studies were designed to determine the glomerular hemodynamic changes responsible for this effect. A first group (PLAC-SAFF) received a diet supplemented with safflower oil (SAFF) (10% of calories) and placebo (PLAC). A second group (CsA-SAFF) received a diet supplemented with SAFF and CsA (10 mg/kg/day). A third group (CsA-EP) also received CsA, but the diet was supplemented with EP oil (10% of calories). Routine micropuncture studies were performed after five to nine weeks of treatment. Single nephron glomerular filtration rate (SNGFR) was lower in CsA-SAFF than in PLAC-SAFF (36 +/- 2 vs. 46 +/- 1 nl/min, p < 0.05). Maintenance of SNGFR in CsA-EP compared to CsA-SAFF (48 +/- 2 nl/min vs. 36 +/- 2 nl/min, P < 0.05) was due to higher values for single nephron plasma flow rate (156 +/- 16 vs. 118 +/- 9off/min, P < 0.05), and higher values for the glomerular capillary ultrafiltration coefficient (0.091 +/- 0.013 vs. 0.054 +/- 0.010 nl/s/mm Hg, P < 0.05). Since dietary fatty acids can affect prostaglandin (PG) production, we measured PGE production in isolated glomeruli. Mean values for basal production rates of PGE were greater in rats maintained on EP than in rats maintained on SAFF (3958 +/- 105 vs. 3378 +/- 146 pg PGE/mg glomerular protein, P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
J W Scholey; D E Mills
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international     Volume:  47     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-05-25     Completed Date:  1995-05-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  611-7     Citation Subset:  IM    
Department of Medicine, University of Toronto, Ontario, Canada.
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MeSH Terms
Cyclosporine / metabolism,  pharmacology*
Dietary Fats / pharmacology*
Eicosanoids / biosynthesis
Fatty Acids, Essential / pharmacology*
Glomerular Filtration Rate / drug effects
Hemodynamics / drug effects
Hypertension / physiopathology*
Kidney Glomerulus / blood supply*,  metabolism
Linoleic Acids
Plant Oils
Rats, Inbred Strains
Safflower Oil / pharmacology
gamma-Linolenic Acid
Reg. No./Substance:
0/Dietary Fats; 0/Eicosanoids; 0/Fatty Acids, Essential; 0/Linoleic Acids; 0/Plant Oils; 506-26-3/gamma-Linolenic Acid; 59865-13-3/Cyclosporine; 65546-85-2/Efamol; 8001-23-8/Safflower Oil

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