| Dietary fatty acids and the aging brain. | |
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MedLine Citation:
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PMID: 21091943 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Aging contributes to physiological decline and vulnerability to disease. In the brain, even with minimal neuronal loss, aging increases oxidative damage, inflammation, demyelination, impaired processing, and metabolic deficits, particularly during pathological brain aging. In this review, the possible role of docosahexaenoic acid (DHA) in the prevention of age-related disruption of brain function is discussed. High-fat diabetogenic diets, cholesterol, and the omega-6 fatty acid arachidonate and its prostaglandin metabolites have all been implicated in promoting the pathogenesis of Alzheimer's disease. Evidence presented here shows DHA acts to oppose this, exerting a plethora of pleiotropic activities to protect against the pathogenesis of Alzheimer's disease. |
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Authors:
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Greg M Cole; Qiu-Lan Ma; Sally A Frautschy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Nutrition reviews Volume: 68 Suppl 2 ISSN: 1753-4887 ISO Abbreviation: Nutr. Rev. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376405 Medline TA: Nutr Rev Country: United States |
Other Details:
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Languages: eng Pagination: S102-11 Citation Subset: IM |
Copyright Information:
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© 2010 International Life Sciences Institute. |
Affiliation:
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Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA. gmcole@ucla.edu |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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AG021975/AG/NIA NIH HHS; R01 AT3008/AT/NCCAM NIH HHS; R01AG13471/AG/NIA NIH HHS |
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