Document Detail


Dietary fatty acids and the aging brain.
MedLine Citation:
PMID:  21091943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aging contributes to physiological decline and vulnerability to disease. In the brain, even with minimal neuronal loss, aging increases oxidative damage, inflammation, demyelination, impaired processing, and metabolic deficits, particularly during pathological brain aging. In this review, the possible role of docosahexaenoic acid (DHA) in the prevention of age-related disruption of brain function is discussed. High-fat diabetogenic diets, cholesterol, and the omega-6 fatty acid arachidonate and its prostaglandin metabolites have all been implicated in promoting the pathogenesis of Alzheimer's disease. Evidence presented here shows DHA acts to oppose this, exerting a plethora of pleiotropic activities to protect against the pathogenesis of Alzheimer's disease.
Authors:
Greg M Cole; Qiu-Lan Ma; Sally A Frautschy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  68 Suppl 2     ISSN:  1753-4887     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2010-12-10     Revised Date:  2014-05-21    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S102-11     Citation Subset:  IM    
Copyright Information:
© 2010 International Life Sciences Institute.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging / metabolism,  physiology*
Brain / drug effects*,  metabolism,  physiology
Dementia / metabolism,  prevention & control
Dietary Fats, Unsaturated / administration & dosage*
Docosahexaenoic Acids / administration & dosage*
Fatty Acids, Omega-3 / administration & dosage,  metabolism
Humans
Grant Support
ID/Acronym/Agency:
AG021975/AG/NIA NIH HHS; R01 AG013741/AG/NIA NIH HHS; R01 AT003008/AT/NCCAM NIH HHS; R01 AT006816/AT/NCCAM NIH HHS; R01 AT3008/AT/NCCAM NIH HHS; R01AG13471/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids, Omega-3; 25167-62-8/Docosahexaenoic Acids
Comments/Corrections

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