Document Detail

Dietary fatty acid supplementation modulates the urinary excretion of calcium and oxalate in the rat. Insight into calcium lithogenesis.
MedLine Citation:
PMID:  12119482     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: An anomalous plasma phospholipid polyunsaturated fatty acid composition has been reported in calcium nephrolithiasis, and was proposed to play a crucial role in the pathogenesis of hypercalciuria and hyperoxaluria, well-known risk factors for lithogenesis. METHODS: To confirm this hypothesis, we administered rats three different diets rich in coconut, soybean and fish oils, and evaluated their effect on plasma urinary calcium and oxalate excretion, since the quality of fatty acids represents an important factor able to influence the activity of delta-6-desaturase, the rate-limiting enzyme in the biosynthetic pathway of highly unsaturated fatty acids. RESULTS: In comparison with coconut and fish oil, dietary supplementation with soybean oil increased plasma phospholipid arachidonic acid and serum 1,25-vitamin D(3) values, as well as renal tissue calcium content and urinary excretion of sodium, oxalate and calcium. CONCLUSIONS: Our findings demonstrate that the quality of fatty acids may modify the urine excretion of calcium and oxalate, confirming our previous hypothesis of a pathogenetic link between cellular membrane phospholipid polyunsaturated fatty acid composition and calcium nephrolithiasis. In addition, our study provides new insights into the relationship between dietary, environmental factors and renal stone disease.
Bruno Baggio; Alessandro Budakovic; Giovanna Priante; Giovanni Gambaro; Enzo Manzato; Saeed Khan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephron     Volume:  91     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-16     Completed Date:  2003-03-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  486-91     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
Department of Medical-Surgery Sciences, Policlinico Universitario, University of Padua, Via Giustiniani 2, I-35120 Padua, Italy.
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MeSH Terms
Arachidonic Acids / blood
Calcium / urine*
Cholecalciferol / blood
Dietary Fats / administration & dosage*
Dietary Supplements*
Fatty Acids / administration & dosage*
Oxalic Acid / urine*
Rats, Sprague-Dawley
Sodium / urine
Reg. No./Substance:
0/Arachidonic Acids; 0/Dietary Fats; 0/Fatty Acids; 144-62-7/Oxalic Acid; 67-97-0/Cholecalciferol; 7440-23-5/Sodium; 7440-70-2/Calcium

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