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Dietary fatty acid composition during pregnancy and the risk of asthma in the offspring.
MedLine Citation:
PMID:  21929596     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
To cite this article: Lumia M, Luukkainen P, Kaila M, Tapanainen H, Erkkola M, Uusitalo L, Niinistö S, Kenward MG, Ilonen J, Simell O, Knip M, Veijola R, Virtanen SM. Dietary fatty acid composition during pregnancy and the risk of asthma in the offspring. Pediatr Allergy Immunol 2011; Doi: 10.1111/j.1399-3038.2011.01202.x ABSTRACT: Background:  Fatty acids (FA) modulate the immune system, and it has been proposed that they affect the incidence of IgE-mediated allergic diseases. We explored the association of maternal dietary FA composition during pregnancy with the risk of asthma in the offspring. Methods:  We analyzed data from the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Nutrition Study. Maternal dietary intake during pregnancy (8th month) was assessed by a validated 181-item food frequency questionnaire. The occurrence of asthma was assessed at the age of 5 yr with a questionnaire modified from the International Study of Asthma and Allergies in Childhood (ISAAC). Cox proportional hazards regression was used for the statistical analyses. Results:  Low maternal intakes of α-linolenic acid (18:3n-3) [lowest quarter vs. mid-half HR 1.67 (95% CI 1.12-2.48)] and total n-3-polyunsaturated fatty acids (PUFA) [HR 1.66 (95% CI 1.11-2.48)] during pregnancy were associated with an increased risk of asthma in the offspring, while a low intake of arachidonic acid (20:4n-6) [HR 0.52 (95% CI 0.32-0.84)] and high intake of total saturated fatty acids [highest quarter vs. mid-half HR 0.55 (95% CI 0.34-0.90)] and palmitic acid (16:0) [HR 0.51 (95% CI 0.31-0.83)] were associated with a decreased risk of asthma. The ratios of n-6 to n-3-PUFA and 18:2n-6 to 18:3n-3, and the maternal intake of oils, fish and fish products, showed no association with the risk of asthma. The associations found were independent of several perinatal and clinical confounders. Conclusion:  Maternal intake of FA during pregnancy was associated with childhood asthma. Maternal α-linolenic acid, total n-3 PUFA and palmitic acid intake may decrease, while arachidonic acid intake may increase the risk of asthma in the offspring.
Authors:
Mirka Lumia; Päivi Luukkainen; Heli Tapanainen; Minna Kaila; Maijaliisa Erkkola; Liisa Uusitalo; Sari Niinistö; Michael G Kenward; Jorma Ilonen; Olli Simell; Mikael Knip; Riitta Veijola; Suvi M Virtanen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-19
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  -     ISSN:  1399-3038     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
Nutrition Unit, Department of Lifestyle and Participation, National Institute of Health and Welfare, Helsinki, Finland School of Health Sciences, FI-33014 University of Tampere, Tampere, Finland Hospital for Children and Adolescents, Helsinki University Hospital, Helsinki, Finland Tampere University Hospital, Department of Pediatrics, Tampere, Finland and University of Helsinki, Hjelt Institute, Helsinki, Finland Division of Nutrition, Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland Department of Public Health, Helsinki University, Helsinki, Finland Department of Epidemiology and Population Health, Medical Statistic Unit, London School of Hygiene and Tropical Medicine, London, UK Immunogenetics Laboratory, 20014 University of Turku, Turku, Finland Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland Department of Pediatrics, University of Turku, Kiinanmyllynkatu, Turku, Finland Department of Pediatrics, Tampere University Hospital, Tampere, Finland Folkhälsan Research Institute, University of Helsinki, Helsinki, Finland Department of Pediatrics, University of Oulu, Oulu, Finland Pediatric Research Centre and Science Center of Pirkanmaa Hospital District, Tampere University Hospital and University of Tampere, Tampere, Finland.
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