Document Detail


Dietary fat saturation affects glucose metabolism without affecting insulin receptor number and affinity in adipocytes from BHE rats.
MedLine Citation:
PMID:  1941189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of dietary fat source on epididymal fat cell insulin receptor binding and affinity and on glucose transport and use by genetically diabetic rats were studied. Male BHE rats were fed 6% fat/64% sucrose diets. The fat consisted of 1% corn oil plus 5% beef tallow, menhaden oil or corn oil. Glucose tolerance was assessed at 100, 300 and 600 d of age. At 100 d of age the fat pads were excised, isolated adipocytes prepared and insulin receptor number, receptor affinity, 3-O-methyl glucose uptake and glucose use determined. Insulin receptor number and binding affinity were not affected by dietary fat type. The transport and subsequent use of glucose were greater in fat cells from rats fed beef tallow compared with those from rats fed corn oil or menhaden oil. All three groups exhibited a deterioration in glucose tolerance with age. Although we observed greater glucose transport, oxidation and conversion to fatty acids in beef tallow-fed rats, we saw no differences in these measurements between cells from corn or menhaden oil-fed rats. Thus, we conclude that the effects of these dietary lipids are attributable to effects of saturated fatty acids on intracellular events rather than on the insulin receptor per se, and that the type of unsaturated fatty acid [(n-3) vs. (n-6)] is of little importance to the regulation of glucose metabolism by isolated adipocytes.
Authors:
J S Pan; C D Berdanier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  121     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1991-12-02     Completed Date:  1991-12-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1811-9     Citation Subset:  IM    
Affiliation:
Department of Foods and Nutrition, University of Georgia, Athens 30602.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / cytology,  drug effects,  metabolism*
Animals
Body Weight
Cattle
Dietary Fats / administration & dosage,  metabolism*,  pharmacology
Glucose / metabolism*
Glucose Tolerance Test
Male
Rats
Rats, Inbred Strains
Receptor, Insulin / drug effects*,  metabolism
Chemical
Reg. No./Substance:
0/Dietary Fats; 50-99-7/Glucose; EC 2.7.10.1/Receptor, Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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