Document Detail

Dietary fat and obesity: a review of animal, clinical and epidemiological studies.
MedLine Citation:
PMID:  15621059     Owner:  NLM     Status:  MEDLINE    
The First Law of Thermodynamics provides a framework for understanding the imbalance between energy intake and expenditure that produces obesity, but it does not help understand the role of genetics, the regulation of food intake, the distribution of body fat, the mechanisms by which diets work or the mechanism by which portion control has gotten out of control. In animals, increasing dietary fat increases body fat, and it is unlikely that humans escape this important biological rule. In epidemiological studies, increasing dietary fat is associated with increased prevalence of obesity probably by increasing the intake of energy dense foods. In the National Weight Loss Registry, three things were associated with weight loss: continued monitoring of food intake, lowering dietary fat intake, and increased exercise. The relation of dietary fat is most evident when physical activity is low. The speed of adaptation to dietary fat is increased by exercise. When dietary fat is reduced, weight is lost, but weight loss eventually plateaus. The rate of weight loss during the initial phase is about 1.6 g/day for each 1% decrease in fat intake. When dietary fat is replaced with olestra to reduce fat intake from 33% to 25% in obese men, weight loss continues for about 9 months reaching a maximum of nearly 6% of body weight and a loss of 18% of initial body fat. In the control group with a 25% reduced-fat diet, weight loss stopped after 3 months and was regained over the next 6 months, indicating the difficulty of adhering to a conventional low-fat diet. Thus, dietary fat is an important contributor to obesity in some people.
George A Bray; Sahasporn Paeratakul; Barry M Popkin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Physiology & behavior     Volume:  83     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-28     Completed Date:  2005-03-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  549-55     Citation Subset:  IM    
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
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MeSH Terms
Animal Experimentation
Body Weight / physiology
Diet Therapy / methods
Dietary Fats / adverse effects*,  metabolism
Epidemiologic Studies*
Exercise / physiology
Obesity* / epidemiology,  etiology,  metabolism,  prevention & control
Reg. No./Substance:
0/Dietary Fats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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