| Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan. | |
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MedLine Citation:
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PMID: 19819467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present case-control study examined the relationship between dietary intake of individual fatty acids and the risk of Parkinson's disease (PD) in Japan. Included were 249 cases within 6 years of onset of PD. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Information on dietary factors was collected using a validated self-administered diet history questionnaire. Compared with arachidonic acid intake in the first quartile, consumption of that in the fourth quartile was significantly related to an increased risk of PD: the adjusted odds ratio between extreme quartiles was 2.09 (95% confidence interval: 1.21-3.64, P for trend=0.008). Cholesterol intake was also significantly positively associated with the risk of PD: the adjusted odds ratio between extreme quartiles was 1.78 (95% confidence interval: 1.04-3.05, P for trend=0.01). Consumption of total fat, saturated fatty acids, monounsaturated fatty acids, n-3 polyunsaturated fatty acids, alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, n-6 polyunsaturated fatty acids, and linoleic acid and the ratio of n-3 to n-6 polyunsaturated fatty acid intake were not associated with PD. Higher consumption of arachidonic acid and cholesterol may be related to an increased risk of PD. |
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Authors:
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Yoshihiro Miyake; Satoshi Sasaki; Keiko Tanaka; Wakaba Fukushima; Chikako Kiyohara; Yoshio Tsuboi; Tatsuo Yamada; Tomoko Oeda; Takami Miki; Nobutoshi Kawamura; Nobutaka Sakae; Hidenao Fukuyama; Yoshio Hirota; Masaki Nagai; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2009-10-12 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 288 ISSN: 1878-5883 ISO Abbreviation: J. Neurol. Sci. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-07 Completed Date: 2010-02-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 117-22 Citation Subset: IM |
Affiliation:
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Department of Public Health, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. miyake-y@fukuoka-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Case-Control Studies Cholesterol, Dietary Diet Surveys Dietary Fats* Fatty Acids Fatty Acids, Omega-3 Female Food Habits / physiology* Humans Japan / epidemiology Logistic Models Male Middle Aged Odds Ratio Parkinson Disease / epidemiology* Questionnaires Socioeconomic Factors |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, Dietary; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Omega-3 |
| Investigator | |
Investigator/Affiliation:
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Yasuhiko Baba / ; Tomonori Kobayashi / ; Hideyuki Sawada / ; Eiji Mizuta / ; Nagako Murase / ; Tsuyoshi Tsutada / ; Hiroyuki Shimada / ; Jun-ichi Kira / ; Tameko Kihira / ; Tomoyoshi Kondo / ; Hidekazu Tomimoto / ; Takayuki Taniwaki / ; Hiroshi Sugiyama / ; Sonoyo Yoshida / ; Harutoshi Fujimura / ; Tomoko Saito / ; Kyoko Saida / ; Junko Fujitake / ; Naoki Fujii / ; Masatoshi Naito / ; Jun Arimizu / ; Takashi Nakagawa / ; Hirofumi Harada / ; Takayuki Sueta / ; Toshihiro Kikuta / ; George Umemoto / ; Eiichi Uchio / ; Hironori Migita / ; Kenichi Kazuki / ; Yoichi Ito / ; Hiroyoshi Iwaki / ; Kunihiko Siraki / ; Shinsuke Ataka / ; Hideo Yaname / ; Rie Tochino / ; Teruichi Harada / ; Yasushi Iwashita / ; Motoyuki Shimizu / ; Kenji Seki / ; Keiji Ando / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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