Document Detail


Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan.
MedLine Citation:
PMID:  19819467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present case-control study examined the relationship between dietary intake of individual fatty acids and the risk of Parkinson's disease (PD) in Japan. Included were 249 cases within 6 years of onset of PD. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Information on dietary factors was collected using a validated self-administered diet history questionnaire. Compared with arachidonic acid intake in the first quartile, consumption of that in the fourth quartile was significantly related to an increased risk of PD: the adjusted odds ratio between extreme quartiles was 2.09 (95% confidence interval: 1.21-3.64, P for trend=0.008). Cholesterol intake was also significantly positively associated with the risk of PD: the adjusted odds ratio between extreme quartiles was 1.78 (95% confidence interval: 1.04-3.05, P for trend=0.01). Consumption of total fat, saturated fatty acids, monounsaturated fatty acids, n-3 polyunsaturated fatty acids, alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, n-6 polyunsaturated fatty acids, and linoleic acid and the ratio of n-3 to n-6 polyunsaturated fatty acid intake were not associated with PD. Higher consumption of arachidonic acid and cholesterol may be related to an increased risk of PD.
Authors:
Yoshihiro Miyake; Satoshi Sasaki; Keiko Tanaka; Wakaba Fukushima; Chikako Kiyohara; Yoshio Tsuboi; Tatsuo Yamada; Tomoko Oeda; Takami Miki; Nobutoshi Kawamura; Nobutaka Sakae; Hidenao Fukuyama; Yoshio Hirota; Masaki Nagai;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2009-10-12
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  288     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  117-22     Citation Subset:  IM    
Affiliation:
Department of Public Health, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. miyake-y@fukuoka-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Case-Control Studies
Cholesterol, Dietary
Diet Surveys
Dietary Fats*
Fatty Acids
Fatty Acids, Omega-3
Female
Food Habits / physiology*
Humans
Japan / epidemiology
Logistic Models
Male
Middle Aged
Odds Ratio
Parkinson Disease / epidemiology*
Questionnaires
Socioeconomic Factors
Chemical
Reg. No./Substance:
0/Cholesterol, Dietary; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Omega-3
Investigator
Investigator/Affiliation:
Yasuhiko Baba / ; Tomonori Kobayashi / ; Hideyuki Sawada / ; Eiji Mizuta / ; Nagako Murase / ; Tsuyoshi Tsutada / ; Hiroyuki Shimada / ; Jun-ichi Kira / ; Tameko Kihira / ; Tomoyoshi Kondo / ; Hidekazu Tomimoto / ; Takayuki Taniwaki / ; Hiroshi Sugiyama / ; Sonoyo Yoshida / ; Harutoshi Fujimura / ; Tomoko Saito / ; Kyoko Saida / ; Junko Fujitake / ; Naoki Fujii / ; Masatoshi Naito / ; Jun Arimizu / ; Takashi Nakagawa / ; Hirofumi Harada / ; Takayuki Sueta / ; Toshihiro Kikuta / ; George Umemoto / ; Eiichi Uchio / ; Hironori Migita / ; Kenichi Kazuki / ; Yoichi Ito / ; Hiroyoshi Iwaki / ; Kunihiko Siraki / ; Shinsuke Ataka / ; Hideo Yaname / ; Rie Tochino / ; Teruichi Harada / ; Yasushi Iwashita / ; Motoyuki Shimizu / ; Kenji Seki / ; Keiji Ando /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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