| Dietary factors and lung function in the general population: wine and resveratrol intake. | |
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MedLine Citation:
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PMID: 21852339 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Wine intake is associated with a better lung function in the general population, yet the source of this effect is unknown. Resveratrol, a polyphenol in wine, has anti-inflammatory properties in the lung, effects being partially mediated via induction of Sirtuin 1 (SIRT1) activity. We assessed the impact of wine and resveratrol intake and SIRT1 SNPs on lung function in the general population. Effects of red and white wine and resveratrol intake on FEV1, FVC and FEV1/FVC were analysed in the population-based Doetinchem cohort (n=3,224). Associations of four tagging SIRT1 SNPs with lung function were analysed in the Doetinchem (n=1,152) and Vlagtwedde-Vlaardingen (n=1,390) cohorts. Resveratrol intake was associated with higher FVC levels and white wine intake with higher FEV1 levels and lower risk of airway obstruction. SIRT1 SNPs were not significantly associated with level or course of lung function, neither directly nor indirectly via wine or resveratrol intake This study shows a positive association of resveratrol intake with lung function in the general population, confirms the previously reported positive association of white wine intake with higher levels of FEV1, and additionally shows an association with a higher FEV1/FVC ratio. These effects do not likely run via SNPs in SIRT1. |
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Authors:
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M Siedlinski; J M A Boer; H A Smit; D S Postma; H M Boezen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-18 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University Medical Center Groningen, University of Groningen, the Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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