Document Detail

Dietary exposure to heterocyclic amines in high-temperature cooked meat and fish in Malaysia.
MedLine Citation:
PMID:  20589547     Owner:  NLM     Status:  MEDLINE    
The intake of heterocyclic amines is influenced by the amount and type of meat and fish ingested, frequency of consumption, cooking methods, cooking temperature, and duration of cooking. In this study, the dietary intake of heterocyclic amines in Malaysia and their main sources were investigated. Forty-two samples of meat and fish were analysed by high-performance liquid chromatography with photodiode array detector to determine the concentration of the six predominant heterocyclic amines, namely: 2-amino-3-methylimidazo[4,5-f] quinoline (IQ), 2-amino-3,4-dimethylimidazo[4,5-f] quinoline(MeIQ), 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f] quinoxaline (4,8-DiMeIQx), 2-amino-3,7,8-trimethylimidazo[4,5-f] quinoxaline (7,8-DiMeIQx), and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Dietary intake data were obtained using a food-frequency questionnaire when interviewing 600 Malaysian respondents. The level of total heterocyclic amines in food samples studies ranged from not detected to 38.7 ng g(-1). The average daily intake level of heterocyclic amine was 553.7 ng per capita day(-1). The intake of PhIP was the highest, followed by MeIQx and MeIQ. The results reveal that fried and grilled chicken were the major dietary source of heterocyclic amines in Malaysia. However, the heterocyclic amine intake by the Malaysian population was lower than those reported from other regions.
M H A Jahurul; S Jinap; S J Ang; A Abdul-Hamid; P Hajeb; H N Lioe; I S M Zaidul
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment     Volume:  27     ISSN:  1944-0057     ISO Abbreviation:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-06-30     Completed Date:  2010-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485040     Medline TA:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Country:  England    
Other Details:
Languages:  eng     Pagination:  1060-71     Citation Subset:  IM    
Faculty of Food Science and Technology, Universiti Putra Malaysia, Center of Excellence for Food Safety Research, 43400 UPM, Selangor, Malaysia.
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MeSH Terms
Amines / administration & dosage*,  analysis,  isolation & purification
Carcinogens / administration & dosage*,  analysis,  isolation & purification
Cross-Sectional Studies
Food Contamination
Heterocyclic Compounds / administration & dosage*,  analysis,  isolation & purification
Hot Temperature / adverse effects*
Limit of Detection
Meat / analysis*
Middle Aged
Nutrition Surveys
Pyridines / administration & dosage,  analysis
Quinolines / administration & dosage,  analysis
Quinoxalines / administration & dosage,  analysis
Seafood / analysis*
Young Adult
Reg. No./Substance:
0/Amines; 0/Carcinogens; 0/Heterocyclic Compounds; 0/Pyridines; 0/Quinolines; 0/Quinoxalines

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