Document Detail

Dietary exposure to chlorpyrifos and levels of 3,5,6-trichloro-2-pyridinol in urine.
MedLine Citation:
PMID:  11571607     Owner:  NLM     Status:  MEDLINE    
Information on associations between chlorpyrifos residues in food and personal exposure to chlorpyrifos would be valuable for evaluating the relationship between personal exposure and possible health effects. We used food consumption records, chlorpyrifos levels in duplicate plates, and measures of 3,5,6-trichloro-2-pyridinol (TCPy) in urine obtained from human volunteers in the National Human Exposure Assessment Survey in Maryland (NHEXAS-MD) to evaluate a food consumption-chemical residue model for estimating dietary intake of chlorpyrifos. Model inputs were the NHEXAS-MD food consumption records and chlorpyrifos residues in specific foods measured in the U.S. Food and Drug Administration Total Diet Study (TDS) market baskets from 1993 to 1997. The estimated mean and standard deviation of chlorpyrifos concentration (microg/kg) in duplicate plates (n=203) were within 20% and 50%, respectively, of the corresponding parameters of measured chlorpyrifos levels. However, predicted and measured concentrations in the 78 duplicate plates with detectable levels of chlorpyrifos were not significantly associated according to Spearman correlation analysis (r=0.04, p=0.7667) and linear regression (p=0.2726). Measured and estimated chlorpyrifos intakes for observations with non-zero values for each intake measure (n=71) were moderately associated on a rank (Spearman's r=0.24, p=0.0462) and linear basis (regression r(2)=0.07, p=0.0242). Measured intakes of chlorpyrifos from food and urinary TCPy were significantly correlated in rank order (n=87, Spearman's r=0.30, p=0.0041) and linear (n=87, Pearson's r=0.22, p=0.0409) analyses. Correlation coefficients between estimated intake of chlorpyrifos from food and TCPy were significantly different from zero (n=87; Spearman's r=0.22, p=0.0393; Pearson's r=0.21, p=0.0479). Comparing mean measured chlorpyrifos intake from food (0.46 microg/day) to mean estimated TCPy excretion via urine (6.3 microg/day), dietary intake of chlorpyrifos accounted for approximately 7% of TCPy in this population. These findings suggest the food consumption-chemical residue model can yield reasonably accurate estimates of the population distribution of dietary chlorpyrifos intake, but has little ability to predict dietary exposure for individuals; and that intake of chlorpyrifos from food is a minor contributor to TCPy in urine.
D L MacIntosh; C Kabiru; S L Echols; P B Ryan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of exposure analysis and environmental epidemiology     Volume:  11     ISSN:  1053-4245     ISO Abbreviation:  J Expo Anal Environ Epidemiol     Publication Date:    2001 Jul-Aug
Date Detail:
Created Date:  2001-09-25     Completed Date:  2001-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111438     Medline TA:  J Expo Anal Environ Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  279-85     Citation Subset:  IM    
Department of Environmental Health Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, Georgia 30602-2102, USA.
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MeSH Terms
Biological Markers / urine
Chlorpyrifos / adverse effects,  analysis*
Environmental Exposure
Food Contamination*
Herbicides / urine*
Insecticides / adverse effects,  analysis*
Models, Theoretical*
Pesticide Residues
Pyridones / urine*
Reg. No./Substance:
0/Biological Markers; 0/Herbicides; 0/Insecticides; 0/Pesticide Residues; 0/Pyridones; 2921-88-2/Chlorpyrifos; 6515-38-4/3,5,6-trichloro-2-pyridinol

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