Document Detail


Dietary exposure to chemical migrants from food contact materials: a probabilistic approach.
MedLine Citation:
PMID:  16236636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A two-dimensional probabilistic model has been developed to estimate the short-term dietary exposure of UK consumers to migrants from food packaging materials. The current EU approach uses a default scenario of assuming that all individuals are 60 kg weight and consume 1 kg of food packaged in the material of interest per day. Using four UK National Dietary and Nutrition Surveys comprising 4-7 day dietary records for different age groups and survey years, a sample representative of the UK population has been obtained consuming around 4200 different food items. Each survey provides records for around 2000 individuals and supplies detailed information on the consumption of food and data on sex, height and socio-economic status which may be used to analyse the exposure of selected groups within the community. As a result we are able to address the variation in consumption of food amongst individuals, and account for actual body weights providing a more accurate representation of the 'true' exposure. The migrants bisphenol A diglycidyl ether (BADGE), di-2-ethylhexyl adipate (DEHA) and styrene were considered as specimen compounds although the methodology employed has the flexibility to adapt to other migrants and packaging types and indeed other food contaminants. Exposure for each individual is estimated by calculating and summing the individual exposure from each item in their diet, and is repeated for all individuals in each survey to produce a distribution of exposures for the population. The packaging type of each food item is assigned by utilizing known packaging types from the database or, by sampling from a distribution based upon market share information. The parameters contributing towards the exposure from a packaged dietary item are migrant concentration and item weight. Distributions are used to represent the inherent variation and uncertainty affecting these parameters. Where data on concentrations for a particular type of food are lacking, expert judgement is used to extrapolate from available data for other food types. The model can also be run using only migration data for food simulants. In this case, concentrations expected for each of the food items are assigned based on the data for the relevant food simulant. The primary outputs of the model are distributions of estimated daily intakes for the selected population. Each distribution gives the variation across the population subject to the uncertain parameters sampled in that iteration of the model. Analysing the ensemble of distributions allows us to obtain the confidence limits around estimates for percentiles due to the uncertainties. The probabilistic approach allows sensitivity analysis to evaluate the relative importance of the input parameters and places confidence bounds on the outputs to show the effect of the uncertainties and the contribution of each food type toward the overall exposure.
Authors:
M J Holmes; A Hart; P Northing; P K T Oldring; L Castle; D Stott; G Smith; O Wardman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Food additives and contaminants     Volume:  22     ISSN:  0265-203X     ISO Abbreviation:  Food Addit Contam     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-20     Completed Date:  2006-02-09     Revised Date:  2013-11-13    
Medline Journal Info:
Nlm Unique ID:  8500474     Medline TA:  Food Addit Contam     Country:  England    
Other Details:
Languages:  eng     Pagination:  907-19     Citation Subset:  IM    
Affiliation:
Department for Environment, Food and Rural Affairs, Central Science Laboratory, Sand Hutton, York, UK.
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MeSH Terms
Descriptor/Qualifier:
Adipates / toxicity
Beverages / analysis,  toxicity
Carcinogens / toxicity
Choice Behavior
Diet
Environmental Exposure / adverse effects
Epoxy Compounds / toxicity
Food Analysis
Food Contamination*
Food Packaging*
Great Britain
Humans
Models, Statistical
Monte Carlo Method
Plasticizers / toxicity
Probability
Styrene / toxicity
Uncertainty
Chemical
Reg. No./Substance:
0/Adipates; 0/Carcinogens; 0/Epoxy Compounds; 0/Plasticizers; 100-42-5/Styrene; 2BD76YG9SI/dioctyl adipate; F3XRM1NX4H/2,2-bis(4-glycidyloxyphenyl)propane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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