Document Detail

Dietary enrichment counteracts age-associated cognitive dysfunction in canines.
MedLine Citation:
PMID:  12392778     Owner:  NLM     Status:  MEDLINE    
Advanced age is accompanied by cognitive decline indicative of central nervous system dysfunction. One possibly critical causal factor is oxidative stress. Accordingly, we studied the effects of dietary antioxidants and age in a canine model of aging that parallels the key features of cognitive decline and neuropathology in humans. Old and young animals were placed on either a standard control food, or a food enriched with a broad spectrum of antioxidants and mitochondrial enzymatic cofactors. After 6 months of treatment, the animals were tested on four increasingly difficult oddity discrimination learning problems. The old animals learned more slowly than the young, making significantly more errors. However, this age-associated decline was reduced in the animals fed the enriched food, particularly on the more difficult tasks. These results indicate that maintenance on foods fortified with complex mixtures of antioxidants can partially counteract the deleterious effects of aging on cognition.
N W Milgram; S C Zicker; E Head; B A Muggenburg; H Murphey; C J Ikeda-Douglas; C W Cotman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurobiology of aging     Volume:  23     ISSN:  0197-4580     ISO Abbreviation:  Neurobiol. Aging     Publication Date:    2002 Sep-Oct
Date Detail:
Created Date:  2002-10-23     Completed Date:  2003-01-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  737-45     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Inc.
Life Science Division, University of Toronto at Scarborough, 1265 Military Trail, Scarborough, Ont, Canada M1C 1A4.
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MeSH Terms
Aging / metabolism*
Animal Feed*
Antioxidants / metabolism,  pharmacology
Ascorbic Acid / pharmacology
Cognition Disorders / diet therapy*,  metabolism*,  prevention & control
Conditioning (Psychology)
Discrimination Learning
Mitochondria / metabolism
Oxidative Stress
alpha-Tocopherol / blood,  pharmacology
Grant Support
Reg. No./Substance:
0/Antioxidants; 50-81-7/Ascorbic Acid; 59-02-9/alpha-Tocopherol

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